Literature DB >> 27908669

Cellular responses to replication stress: Implications in cancer biology and therapy.

Hui-Ju Hsieh1, Guang Peng2.   

Abstract

DNA replication is essential for cell proliferation. Any obstacles during replication cause replication stress, which may lead to genomic instability and cancer formation. In this review, we summarize the physiological DNA replication process and the normal cellular response to replication stress. We also outline specialized therapies in clinical trials based on current knowledge and future perspectives in the field.
Copyright © 2016 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Cancer; Clinical trials; DNA replication; Genomic instability; Replication stress

Mesh：

Substances：

Year:  2016        PMID： 27908669     DOI： 10.1016/j.dnarep.2016.11.002

Source DB:  PubMed          Journal:  DNA Repair (Amst)        ISSN： 1568-7856


  7 in total

1.  Rad9/53BP1 protects stalled replication forks from degradation in Mec1/ATR-defective cells.

Authors:  Matteo Villa; Diego Bonetti; Massimo Carraro; Maria Pia Longhese
Journal:  EMBO Rep       Date:  2018-01-04       Impact factor: 8.807

Review 2.  Transcribing malignancy: transcription-associated genomic instability in cancer.

Authors:  B Boulianne; N Feldhahn
Journal:  Oncogene       Date:  2017-11-06       Impact factor: 9.867

Review 3.  Perturbations in the Replication Program Contribute to Genomic Instability in Cancer.

Authors:  Britny Blumenfeld; Micha Ben-Zimra; Itamar Simon
Journal:  Int J Mol Sci       Date:  2017-05-25       Impact factor: 5.923

4.  Long noncoding RNA MEG3, a potential novel biomarker to predict the clinical outcome of cancer patients: a meta-analysis.

Authors:  Xiangrong Cui; Xuan Jing; Chunlan Long; Jie Tian; Jing Zhu
Journal:  Oncotarget       Date:  2017-03-21

5.  Supraphysiological protection from replication stress does not extend mammalian lifespan.

Authors:  Eliene Albers; Alexandra Avram; Mauro Sbroggio; Oscar Fernandez-Capetillo; Andres J Lopez-Contreras
Journal:  Aging (Albany NY)       Date:  2020-04-06       Impact factor: 5.682

6.  Rapid evolution and molecular convergence in cryptorchidism-related genes associated with inherently undescended testes in mammals.

Authors:  Simin Chai; Ran Tian; Juanjuan Bi; Shixia Xu; Guang Yang; Wenhua Ren
Journal:  BMC Ecol Evol       Date:  2021-02-10

Review 7.  Targeting Replication Stress Response Pathways to Enhance Genotoxic Chemo- and Radiotherapy.

Authors:  Jac A Nickoloff
Journal:  Molecules       Date:  2022-07-25       Impact factor: 4.927
  7 in total

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