Literature DB >> 27904704

LncRNA Sox2ot overexpression serves as a poor prognostic biomarker in gastric cancer.

Yuanyuan Zhang1, Rui Yang2, Jianchun Lian1, Haiyan Xu3.   

Abstract

Sox2 overlapping transcript (Sox2ot) serves as an unfavorable prognostic factor in lung cancer and hepatocellular carcinoma, but the clinical significance and biological function of Sox2ot in gastric cancer is still unknown. The objective of our research is to explore the significance of Sox2ot in gastric cancer. Quantitative real-time polymerase chain reaction was performed to determine Sox2ot in gastric cancer tissues and cell lines. Furthermore, the Sox2ot status in one hundred and thirty two gastric cancer samples was detected to analyzed correlations between Sox2ot and clinicopathological features. The biological function of Sox2ot on tumor cell growth and mobility were explored through MTT, colony formation, Transwell migration assay and invasion assay in vitro. In our results, the expression of Sox2ot was overexpressed in gastric cancer tissues and cell lines. High levels of Sox2ot were correlated with malignant status and poor prognosis. Silencing Sox2ot expression effectively inhibited gastric cancer cell growth and motility in vitro. In conclusion, Sox2ot is a potential therapeutic target and a new biomarker for gastric cancer patients.

Entities:  

Keywords:  Sox2ot; biomarker; gastric cancer; lncRNA

Year:  2016        PMID： 27904704      PMCID： PMC5126346     

Source DB:  PubMed          Journal:  Am J Transl Res            Impact factor:   4.060


  37 in total

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7.  Two novel splice variants of SOX2OT, SOX2OT-S1, and SOX2OT-S2 are coupregulated with SOX2 and OCT4 in esophageal squamous cell carcinoma.

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Authors:  Marjan E Askarian-Amiri; Vahid Seyfoddin; Chanel E Smart; Jingli Wang; Ji Eun Kim; Herah Hansji; Bruce C Baguley; Graeme J Finlay; Euphemia Y Leung
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  36 in total

1.  The SOX2OT/miR-194-5p axis regulates cell proliferation and mobility of gastric cancer through suppressing epithelial-mesenchymal transition.

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4.  LncARSR promotes non-small-cell lung cancer progression via regulating PTEN/Akt.

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5.  LncRNA CERNA2 is an independent predictor for clinical prognosis and is related to tumor development in gastric cancer.

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6.  Testing lncRNAs signature as clinical stage-related prognostic markers in gastric cancer progression using TCGA database.

Authors:  Narasimha M Beeraka; Hao Gu; Nannan Xue; Yang Liu; Huiming Yu; Junqi Liu; Kuo Chen; Vladimir N Nikolenko; Ruitai Fan
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7.  Microarray data re-annotation reveals specific lncRNAs and their potential functions in non-small cell lung cancer subtypes.

Authors:  Dongbo Zhou; Mingxuan Xie; Baimei He; Ying Gao; Qiao Yu; Bixiu He; Qiong Chen
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8.  Prognostic value of lncRNA SOX2OT for Chinese cancer patients: A meta-analysis.

Authors:  Xuran Jing; Jieru Lin; Hongwei Wang; Liyuan Tian; Runhua Tian; Yunyuan Zhang; Xian Chen; Jinyu Zhang
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9.  Overexpression of long non-coding RNA SOX2OT promotes esophageal squamous cell carcinoma growth.

Authors:  Yuanyuan Wu; Xuedan Chen; Yan Liang; Juan Li; Kun Zhang; Limeng Dai; Xingying Guan; Kai Wang; Yun Bai
Journal:  Cancer Cell Int       Date:  2018-05-25       Impact factor: 5.722

10.  LncRNA SOX2OT alleviates mesangial cell proliferation and fibrosis in diabetic nephropathy via Akt/mTOR-mediated autophagy.

Authors:  Ke Chen; Bo Yu; Jie Liao
Journal:  Mol Med       Date:  2021-07-08       Impact factor: 6.354
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