LncRNA PTCSC3 suppressed cervical carcinoma cell invasion and proliferation via regulating miR-574-5p.

LncRNAs have been shown to invovled in the development of various cancers. However, the function and potential mechanism of PTCSC3 in cervical carcinoma progression remains unknown. In this reference, we showed that PTCSC3 expression was downregulated in 4 cervical carcinoma cell lines (Caski, Siha, Hela and C4-1) compared to control cell line (GH329). Expression of PTCSC3 was downregulated in cervical carcinoma samples compared to non-cancerous samples. Ectopic expression of PTCSC3 inhibited miR-574-5p expression and enhanced the expression of SCAI both in Hela cell and Siha cell. We proved that the miR-574-5p expression was overexpressed in 4 cervical carcinoma cell lines (Caski, Siha, Hela and C4-1) compared to control cell line (GH329). Expression of miR-574-5p was overexpressed in cervical carcinoma samples compared to non-cancerous samples. Furthermore, we indicated that expression of miR-574-5p was negatively correlated with expression of PTCSC3 in cervical carcinoma. Ectopic expression of PTCSC3 decreased cell proliferation and invasion. Finally, we indicated that PTCSC3 overexpression suppressed cervical carcinoma progression via regulating miR-574-5p expression. These data suggested that PTCSC3 played as an oncogene in progression of cervical carcinoma. AJTR