Literature DB >> 27897158

IQGAP1 makes PI(3)K signalling as easy as PIP, PIP2, PIP3.

Lucia E Rameh1, Ashley M Mackey2.   

Abstract

Despite being one of the most studied signalling pathways, precisely how phospholipid synthesis is regulated in the phosphoinositide signalling cascade remains unclear. The scaffold protein IQGAP1 is now shown to orchestrate the assembly of a multi-enzyme complex that streamlines PtdIns(3,4,5)P3 synthesis to facilitate Akt activation in response to extracellular stimuli.

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Year:  2016        PMID： 27897158     DOI： 10.1038/ncb3440

Source DB:  PubMed          Journal:  Nat Cell Biol        ISSN： 1465-7392            Impact factor:   28.824


  12 in total

1.  A peptide model system for processive phosphorylation by Src family kinases.

Authors:  M P Scott; W T Miller
Journal:  Biochemistry       Date:  2000-11-28       Impact factor: 3.162

2.  Plentiful PtdIns5P from scanty PtdIns(3,5)P2 or from ample PtdIns? PIKfyve-dependent models: Evidence and speculation (response to: DOI 10.1002/bies.201300012).

Authors:  Assia Shisheva; Diego Sbrissa; Ognian Ikonomov
Journal:  Bioessays       Date:  2014-11-18       Impact factor: 4.345

3.  Evidence that SH2 domains promote processive phosphorylation by protein-tyrosine kinases.

Authors:  B J Mayer; H Hirai; R Sakai
Journal:  Curr Biol       Date:  1995-03-01       Impact factor: 10.834

4.  Purification and characterization of phosphoinositide 3-kinase from rat liver.

Authors:  C L Carpenter; B C Duckworth; K R Auger; B Cohen; B S Schaffhausen; L C Cantley
Journal:  J Biol Chem       Date:  1990-11-15       Impact factor: 5.157

5.  Serum withdrawal-induced accumulation of phosphoinositide 3-kinase lipids in differentiating 3T3-L6 myoblasts: distinct roles for Ship2 and PTEN.

Authors:  Adel Mandl; Deborah Sarkes; Valerie Carricaburu; Vanessa Jung; Lucia Rameh
Journal:  Mol Cell Biol       Date:  2007-09-24       Impact factor: 4.272

6.  IQGAP1 scaffold-kinase interaction blockade selectively targets RAS-MAP kinase-driven tumors.

Authors:  Katherine L Jameson; Pawel K Mazur; Ashley M Zehnder; Jiajing Zhang; Brian Zarnegar; Julien Sage; Paul A Khavari
Journal:  Nat Med       Date:  2013-04-21       Impact factor: 53.440

Review 7.  IQGAPs in cancer: a family of scaffold proteins underlying tumorigenesis.

Authors:  Colin D White; Matthew D Brown; David B Sacks
Journal:  FEBS Lett       Date:  2009-05-09       Impact factor: 4.124

8.  PIPPing on AKT1: How Many Phosphatases Does It Take to Turn off PI3K?

Authors:  Alex Toker; Lucia Rameh
Journal:  Cancer Cell       Date:  2015-08-10       Impact factor: 31.743

Review 9.  Control of diverse subcellular processes by a single multi-functional lipid phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2].

Authors:  Sourav Kolay; Urbashi Basu; Padinjat Raghu
Journal:  Biochem J       Date:  2016-06-15       Impact factor: 3.857

10.  A quantitative model of ERK MAP kinase phosphorylation in crowded media.

Authors:  Kazuhiro Aoki; Koichi Takahashi; Kazunari Kaizu; Michiyuki Matsuda
Journal:  Sci Rep       Date:  2013       Impact factor: 4.379
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  2 in total

Review 1.  Phosphoinositide 3-kinase pathways and autophagy require phosphatidylinositol phosphate kinases.

Authors:  Suyong Choi; Xander Houdek; Richard A Anderson
Journal:  Adv Biol Regul       Date:  2018-02-08

2.  Inositol-requiring enzyme-1 regulates phosphoinositide signaling lipids and macrophage growth.

Authors:  Syed Muhammad Hamid; Mevlut Citir; Erdem Murat Terzi; Ismail Cimen; Zehra Yildirim; Asli Ekin Dogan; Begum Kocaturk; Umut Inci Onat; Moshe Arditi; Christian Weber; Alexis Traynor-Kaplan; Carsten Schultz; Ebru Erbay
Journal:  EMBO Rep       Date:  2020-11-02       Impact factor: 9.071
  2 in total

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