Literature DB >> 26267528

PIPPing on AKT1: How Many Phosphatases Does It Take to Turn off PI3K?

Alex Toker1, Lucia Rameh2.   

Abstract

In this issue of Cancer Cell, Ooms and colleagues show that the lipid phosphatase PIPP/INPP5J, frequently inactivated in triple-negative breast cancers, functions as a tumor suppressor by specifically modulating the activity of AKT1 in the context of oncogenic PI3K signaling, leading to inhibition of metastatic dissemination.
Copyright © 2015 Elsevier Inc. All rights reserved.

Entities:  

Mesh：

Substances：

Year:  2015        PMID： 26267528     DOI： 10.1016/j.ccell.2015.07.010

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  6 in total

1.  IQGAP1 makes PI(3)K signalling as easy as PIP, PIP2, PIP3.

Authors:  Lucia E Rameh; Ashley M Mackey
Journal:  Nat Cell Biol       Date:  2016-11-29       Impact factor: 28.824

Review 2.  The impact of phosphoinositide 5-phosphatases on phosphoinositides in cell function and human disease.

Authors:  Ana Raquel Ramos; Somadri Ghosh; Christophe Erneux
Journal:  J Lipid Res       Date:  2018-09-07       Impact factor: 5.922

3.  Involvement of CaMKII in regulating the release of diplotene-arrested mouse oocytes by pAkt1 (Ser473).

Authors:  Lingling Liu; Hanwen Li; Ben Labbe; Yang Wang; Shitao Mao; Yu Cao; Mingjing Zhao; Shuo Liu; Hang Yu; Xin Deng
Journal:  Cell Cycle       Date:  2019-09-18       Impact factor: 4.534

4.  Angiosarcoma of an Arteriovenous Fistula for Hemodialysis in a Kidney Transplant Recipient Affected by Lowe's Syndrome.

Authors:  V D'Ambrosio; P Silvestri; F Aureli; A Sturniolo; G Grandaliano; P M Ferraro
Journal:  Case Rep Nephrol       Date:  2020-04-13

5.  Activation of PAR2 by tissue factor induces the release of the PTEN from MAGI proteins and regulates PTEN and Akt activities.

Authors:  Mohammad A Mohammad; John Greenman; Anthony Maraveyas; Camille Ettelaie
Journal:  Sci Rep       Date:  2020-12-01       Impact factor: 4.379

6.  Thyroid Hormone Receptor Beta Inhibits PI3K-Akt-mTOR Signaling Axis in Anaplastic Thyroid Cancer via Genomic Mechanisms.

Authors:  Cole D Davidson; Eric L Bolf; Noelle E Gillis; Lauren M Cozzens; Jennifer A Tomczak; Frances E Carr
Journal:  J Endocr Soc       Date:  2021-06-01
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.