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Literature DB >> 2789189

Expression of the Q8/9d gene by T cells of the mouse.

A Matsuura¹, R Schloss, F W Shen, J S Tung, S W Hunt, D A Fisher, L E Hood, E A Boyse.

Abstract

The Q genes, specifying Qa antigens and situated in the extended part of the major histocompatibility complex (MHC) of the mouse, comprise a subgroup of MHC class I genes whose significance and function are still largely unknown. In screening a cDNA library made from the BALB/c inducer T-cell line Cl.Ly1-T1, we isolated 11 clones representing Q8/9, but none representing Q6 or Q7. Confirmatory evidence is given that the Q8/9 gene originated from fusion of the 5' region of the Q8 gene with the 3' region of the Q9 gene at a recombination site or hot spot in the vicinity of intron 4. Contrary to previous impressions that Q8/9 is an inert pseudogene, we find that the Q8/9 gene can be functional and encode a Qa-2, 3 antigen. One variety of the 11 Q8/9 clones isolated lacked exon 5, which encodes the transmembrane domain of class I glycoproteins, and thus may account for secretion of a soluble form of Qa-2, 3 antigen thought to be released by activated T cells.

Entities: Gene Species

Mesh：

Substances：

Year: 1989 PMID： 2789189 DOI： 10.1007/bf02421200

Source DB: PubMed Journal: Immunogenetics ISSN： 0093-7711 Impact factor: 2.846

24 in total

1. A single gene encodes soluble and membrane-bound forms of the major histocompatibility Qa-2 antigen: anchoring of the product by a phospholipid tail.

Authors: I Stroynowski; M Soloski; M G Low; L Hood
Journal: Cell Date: 1987-08-28 Impact factor: 41.582

2. Transcripts of Tla genes.

Authors: A Matsuura; F W Shen; D A Fisher; L Hood; E A Boyse
Journal: Immunogenetics Date: 1987 Impact factor: 2.846

3. DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells.

Authors: M Wigler; A Pellicer; S Silverstein; R Axel; G Urlaub; L Chasin
Journal: Proc Natl Acad Sci U S A Date: 1979-03 Impact factor: 11.205

4. A nonpolymorphic class I gene in the murine major histocompatibility complex.

Authors: A L Mellor; E H Weiss; M Kress; G Jay; R A Flavell
Journal: Cell Date: 1984-01 Impact factor: 41.582

5. Structure and expression of genes encoding murine Qa-2 class I antigens.

Authors: A L Mellor; J Antoniou; P J Robinson
Journal: Proc Natl Acad Sci U S A Date: 1985-09 Impact factor: 11.205

6. Molecular mapping of signals in the Qa-2 antigen required for attachment of the phosphatidylinositol membrane anchor.

Authors: G L Waneck; D H Sherman; P W Kincade; M G Low; R A Flavell
Journal: Proc Natl Acad Sci U S A Date: 1988-01 Impact factor: 11.205

7. Three cDNA clones encoding mouse transplantation antigens: homology to immunoglobulin genes.

Authors: M Steinmetz; J G Frelinger; D Fisher; T Hunkapiller; D Pereira; S M Weissman; H Uehara; S Nathenson; L Hood
Journal: Cell Date: 1981-04 Impact factor: 41.582

8. A pseudogene homologous to mouse transplantation antigens: transplantation antigens are encoded by eight exons that correlate with protein domains.

Authors: M Steinmetz; K W Moore; J G Frelinger; B T Sher; F W Shen; E A Boyse; L Hood
Journal: Cell Date: 1981-09 Impact factor: 41.582

Expression of the Q8/9d gene by T cells of the mouse.

1. A single gene encodes soluble and membrane-bound forms of the major histocompatibility Qa-2 antigen: anchoring of the product by a phospholipid tail.

2. Transcripts of Tla genes.

3. DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells.

4. A nonpolymorphic class I gene in the murine major histocompatibility complex.

5. Structure and expression of genes encoding murine Qa-2 class I antigens.

6. Molecular mapping of signals in the Qa-2 antigen required for attachment of the phosphatidylinositol membrane anchor.

7. Three cDNA clones encoding mouse transplantation antigens: homology to immunoglobulin genes.

8. A pseudogene homologous to mouse transplantation antigens: transplantation antigens are encoded by eight exons that correlate with protein domains.

9. Thymus-leukemia (TL) antigens of the mouse. Analysis of TL mRNA and TL cDNA TL+ and TL- strains.

10. Synthesis and processing of molecules bearing thymus leukemia antigen.

1. A physical map of the Q region of B1O.P.

2. MHC gene Q8/9d of the BALB/cJ mouse strain cannot encode a Qa-2,3 class I antigen.

3. Expression and regulation of Q8b in a transfected cell line.

4. A new polymorphic and multicopy MHC gene family related to nonmammalian class I.

5. Activated T cells transcribe an alternatively spliced mRNA encoding a soluble form of Qa-2 antigen.

6. New nucleotide sequence data on the EMBL File Server.