Literature DB >> 2789121

The effect of transforming growth factor-beta on mouse mesangial cell proliferation.

W Yamashita1, E P MacCarthy, A Hsu, P S Gartside, B S Ooi.   

Abstract

The factors which regulate mesangial cell growth are of importance in determining the cellular lesions of nephritis. In this communication, we report that transforming growth factor-beta (TGF-beta) exerts a suppressive effect on mesangial cell 3H-thymidine uptake. Furthermore, TGF-beta antagonizes the mitogenic effect of epidermal growth factor (EGF) on DNA synthesis. The concomitant presence of TGF-beta in the cell cultures is not required for its effect since cells pretreated with the substance and rinsed of it showed suppressed 3H-thymidine uptake and did not respond to EGF. The effect of TGF-beta can also be demonstrated on cells committed to proliferate by the prior addition of EGF. The results of the study have relevance to the mechanisms underlying the histologic lesions of immune-mediated nephritis.

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Year:  1989        PMID： 2789121      PMCID： PMC1542002     

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  14 in total

1.  Anchorage-independent growth of primary rat embryo cells is induced by platelet-derived growth factor and inhibited by type-beta transforming growth factor.

Authors:  M A Anzano; A B Roberts; M B Sporn
Journal:  J Cell Physiol       Date:  1986-02       Impact factor: 6.384

2.  Modulation of mouse mesangial cell proliferation by macrophage products.

Authors:  E P MacCarthy; A Hsu; Y M Ooi; B S Ooi
Journal:  Immunology       Date:  1985-12       Impact factor: 7.397

3.  Type beta transforming growth factor: a bifunctional regulator of cellular growth.

Authors:  A B Roberts; M A Anzano; L M Wakefield; N S Roche; D F Stern; M B Sporn
Journal:  Proc Natl Acad Sci U S A       Date:  1985-01       Impact factor: 11.205

4.  Interleukin 1, a potential regulator of fibroblast proliferation.

Authors:  J A Schmidt; S B Mizel; D Cohen; I Green
Journal:  J Immunol       Date:  1982-05       Impact factor: 5.422

5.  Stimulation of rat mesangial cell proliferation by macrophage interleukin 1.

Authors:  D H Lovett; J L Ryan; R B Sterzel
Journal:  J Immunol       Date:  1983-12       Impact factor: 5.422

6.  Mechanisms of suppression of mouse mesangial cell proliferation by macrophage supernatants.

Authors:  Y M Ooi; M A Weiss; A Hsu; B S Ooi
Journal:  J Immunol       Date:  1983-04       Impact factor: 5.422

7.  Human plasma epidermal growth factor/beta-urogastrone is associated with blood platelets.

Authors:  Y Oka; D N Orth
Journal:  J Clin Invest       Date:  1983-07       Impact factor: 14.808

8.  Transforming growth factor-beta in human platelets. Identification of a major storage site, purification, and characterization.

Authors:  R K Assoian; A Komoriya; C A Meyers; D M Miller; M B Sporn
Journal:  J Biol Chem       Date:  1983-06-10       Impact factor: 5.157

9.  Beta-endorphin amplifies the effect of interleukin-1 on mouse mesangial cell proliferation.

Authors:  B S Ooi; E P MacCarthy; A Hsu
Journal:  J Lab Clin Med       Date:  1987-08

10.  Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth.

Authors:  J H Kehrl; L M Wakefield; A B Roberts; S Jakowlew; M Alvarez-Mon; R Derynck; M B Sporn; A S Fauci
Journal:  J Exp Med       Date:  1986-05-01       Impact factor: 14.307
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  1 in total

1.  Transforming growth factor beta 2 differentially modulates interleukin-1 beta- and tumour-necrosis-factor-alpha-stimulated phospholipase A2 and prostaglandin E2 synthesis in rat renal mesangial cells.

Authors:  J Pfeilschifter; W Pignat; J Leighton; F Märki; K Vosbeck; S Alkan
Journal:  Biochem J       Date:  1990-08-15       Impact factor: 3.857
  1 in total

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