Literature DB >> 2396988

Transforming growth factor beta 2 differentially modulates interleukin-1 beta- and tumour-necrosis-factor-alpha-stimulated phospholipase A2 and prostaglandin E2 synthesis in rat renal mesangial cells.

J Pfeilschifter1, W Pignat, J Leighton, F Märki, K Vosbeck, S Alkan.   

Abstract

Treatment of rat glomerular mesangial cells with transforming growth factor beta 2 (TGF beta 2) stimulates prostaglandin E2 (PGE2) synthesis. Actinomycin D, cycloheximide and diclofenac attenuate the TGF beta 2-induced PGE2 formation. As shown previously, two proinflammatory cytokines, interleukin 1 beta (IL-1 beta) and tumour necrosis factor alpha (TNF alpha), are potent stimuli for PGE2 and phospholipase A2 secretion from mesangial cells. We report here that, whereas TGF beta 2 potentiates the IL-1 beta- and TNF alpha-evoked PGE2 production, it strongly inhibits the phospholipase A2 secretion induced by both cytokines. In addition, the inhibitory effect of TGF beta 2 on phospholipase A2 secretion is not due to the augmented PGE2 formation.

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Year:  1990        PMID： 2396988      PMCID： PMC1131710          DOI： 10.1042/bj2700269

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  25 in total

1.  Purification and properties of a type beta transforming growth factor from bovine kidney.

Authors:  A B Roberts; M A Anzano; C A Meyers; J Wideman; R Blacher; Y C Pan; S Stein; S R Lehrman; J M Smith; L C Lamb
Journal:  Biochemistry       Date:  1983-12-06       Impact factor: 3.162

2.  Purification and initial characterization of a type beta transforming growth factor from human placenta.

Authors:  C A Frolik; L L Dart; C A Meyers; D M Smith; M B Sporn
Journal:  Proc Natl Acad Sci U S A       Date:  1983-06       Impact factor: 11.205

3.  Antigen-induced proliferation assay for mouse T lymphocytes. Response to a monovalent antigen.

Authors:  S S Alkan
Journal:  Eur J Immunol       Date:  1978-02       Impact factor: 5.532

4.  Interleukin I and the glomerular mesangium. II. Monokine stimulation of mesangial cell prostanoid secretion.

Authors:  D H Lovett; K Resch; D Gemsa
Journal:  Am J Pathol       Date:  1987-12       Impact factor: 4.307

5.  Prostaglandin E2 production is synergistically increased in cultured human glomerular mesangial cells by combinations of IL-1 and tumor necrosis factor-alpha 1.

Authors:  N Topley; J Floege; K Wessel; R Hass; H H Radeke; V Kaever; K Resch
Journal:  J Immunol       Date:  1989-09-15       Impact factor: 5.422

6.  Endogenous suppression of neutral-active and calcium-dependent phospholipase A2 in human polymorphonuclear leukocytes.

Authors:  F Märki; R Franson
Journal:  Biochim Biophys Acta       Date:  1986-11-14

7.  Activation of phospholipase C and prostaglandin synthesis by [arginine]vasopressin in cultures.

Authors:  J Pfeilschifter; A Kurtz; C Bauer
Journal:  Biochem J       Date:  1984-11-01       Impact factor: 3.857

Review 8.  Hormonal modulation of glomerular function.

Authors:  L D Dworkin; I Ichikawa; B M Brenner
Journal:  Am J Physiol       Date:  1983-02

9.  Inflammatory effect of intradermal administration of soluble phospholipase A2 in rabbits.

Authors:  W Pruzanski; P Vadas; V Fornasier
Journal:  J Invest Dermatol       Date:  1986-04       Impact factor: 8.551

10.  Transforming growth factor-beta in human platelets. Identification of a major storage site, purification, and characterization.

Authors:  R K Assoian; A Komoriya; C A Meyers; D M Miller; M B Sporn
Journal:  J Biol Chem       Date:  1983-06-10       Impact factor: 5.157
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  8 in total

1.  Role of transforming growth factor-β2 in, and apossible transforming growth factor-β 2 gene polymorphism as a marker of, renal dysfunction in essential hypertension: A study in Turkish patients.

Authors:  Zerrin Bicik; Sevim Gönen; Talat Bahçebasi; Kadriye Reis; Turgay Arinsoy; Sükrü Sindel
Journal:  Curr Ther Res Clin Exp       Date:  2005-07

2.  FTY720 suppresses interleukin-1beta-induced secretory phospholipase A2 expression in renal mesangial cells by a transcriptional mechanism.

Authors:  C Xin; S Ren; W Eberhardt; J Pfeilschifter; A Huwiler
Journal:  Br J Pharmacol       Date:  2007-02-26       Impact factor: 8.739

3.  The ω3-polyunsaturated fatty acid derivatives AVX001 and AVX002 directly inhibit cytosolic phospholipase A(2) and suppress PGE(2) formation in mesangial cells.

Authors:  Andrea Huwiler; Astrid J Feuerherm; Benjamin Sakem; Oleksandr Pastukhov; Iuliia Filipenko; Thuy Nguyen; Berit Johansen
Journal:  Br J Pharmacol       Date:  2012-12       Impact factor: 8.739

4.  Cytokine regulation of group II phospholipase A2 expression in glomerular mesangial cells.

Authors:  J Pfeilschifter; H Mühl; W Pignat; F Märki; H van den Bosch
Journal:  Eur J Clin Pharmacol       Date:  1993       Impact factor: 2.953

5.  Role of transforming growth factor-beta in maintenance of function of cultured neonatal cardiac myocytes. Autocrine action and reversal of damaging effects of interleukin-1.

Authors:  A B Roberts; N S Roche; T S Winokur; J K Burmester; M B Sporn
Journal:  J Clin Invest       Date:  1992-11       Impact factor: 14.808

6.  Lysyl oxidase binds transforming growth factor-beta and regulates its signaling via amine oxidase activity.

Authors:  Phimon Atsawasuwan; Yoshiyuki Mochida; Michitsuna Katafuchi; Masaru Kaku; Keith S K Fong; Katalin Csiszar; Mitsuo Yamauchi
Journal:  J Biol Chem       Date:  2008-10-02       Impact factor: 5.157

7.  Inhibition of cytokine-induced nitric oxide production by transforming growth factor-beta 1 in human smooth muscle cells.

Authors:  D C Junquero; T Scott-Burden; V B Schini; P M Vanhoutte
Journal:  J Physiol       Date:  1992-08       Impact factor: 5.182

Review 8.  Bench-to-bedside review: Ventilation-induced renal injury through systemic mediator release--just theory or a causal relationship?

Authors:  Jan Willem Kuiper; Rosanna Vaschetto; Francesco Della Corte; Frans B Plötz; A B Johan Groeneveld
Journal:  Crit Care       Date:  2011-08-16       Impact factor: 9.097
  8 in total

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