T V Kvist1, J S Lindholt2, L M Rasmussen3, R Søgaard4, J Lambrechtsen5, F H Steffensen6, L Frost7, M H Olsen3, H Mickley8, J Hallas9, G Urbonaviciene7, M Busk6, K Egstrup5, A C P Diederichsen10. 1. Elitary Research Centre of Individualised Medicine in Arterial Disease (CIMA), Odense, Denmark. Electronic address: thomasvedelkvist@gmail.com. 2. Elitary Research Centre of Individualised Medicine in Arterial Disease (CIMA), Odense, Denmark; Department of Cardiothoracic and Vascular Surgery, Odense University Hospital, Odense, Denmark. 3. Elitary Research Centre of Individualised Medicine in Arterial Disease (CIMA), Odense, Denmark. 4. Department of Public Health and Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. 5. Department of Cardiology, University Hospital Odense Svendborg, Svendborg, Denmark. 6. Department of Cardiology, Vejle Hospital, Vejle, Denmark. 7. Department of Cardiology, Diagnostic Centre, Regional Hospital Silkeborg, Silkeborg, Denmark. 8. Department of Cardiology, Odense University Hospital, Odense C, Denmark. 9. Institute of Pharmacology, University of Southern Denmark, Odense C, Denmark. 10. Elitary Research Centre of Individualised Medicine in Arterial Disease (CIMA), Odense, Denmark; Department of Cardiology, Odense University Hospital, Odense C, Denmark.
Abstract
OBJECTIVE/ BACKGROUND: This pilot study of a large population based randomised screening trial investigated feasibility, acceptability, and relevance (prevalence of clinical and subclinical cardiovascular disease [CVD] and proportion receiving insufficient prevention) of a multifaceted screening for CVD. METHODS: In total, 2060 randomly selected Danish men and women aged 65-74 years were offered (i) low dose non-contrast computed tomography to detect coronary artery calcification (CAC) and aortic/iliac aneurysms; (ii) detection of atrial fibrillation (AF); (iii) brachial and ankle blood pressure measurements; and (iv) blood levels of cholesterol and hemoglobin A1c. Web based self booking and data management was used to reduce the administrative burden. RESULTS: Attendance rates were 64.9% (n = 678) and 63.0% (n = 640) for men and women, respectively. In total, 39.7% received a recommendation for medical preventive actions. Prevalence of aneurysms was 12.4% (95% confidence interval [CI] 9.9-14.9) in men and 1.1% (95% CI 0.3-1.9) in women, respectively (p < .001). A CAC score > 400 was found in 37.8% of men and 11.3% of women (p < .001), along with a significant increase in median CAC score with age (p = .03). Peripheral arterial disease was more prevalent in men (18.8%, 95% CI 15.8-21.8) than in women (11.2%, 95% CI 8.7-13.6). No significant differences between the sexes were found with regard to newly discovered AF (men 1.3%, women 0.5%), potential hypertension (men 9.7%, women 11.5%), hypercholesterolemia (men 0.9%, women 1.1%) or diabetes mellitus (men 2.1%, women 1.3%). CONCLUSION: Owing to the higher prevalence of severe conditions, such as aneurysms and CAC ≥ 400, screening for CVD seemed more prudent in men than women. The attendance rates were acceptable compared with other screening programs and the logistical structure of the screening program proved successful.
OBJECTIVE/ BACKGROUND: This pilot study of a large population based randomised screening trial investigated feasibility, acceptability, and relevance (prevalence of clinical and subclinical cardiovascular disease [CVD] and proportion receiving insufficient prevention) of a multifaceted screening for CVD. METHODS: In total, 2060 randomly selected Danish men and women aged 65-74 years were offered (i) low dose non-contrast computed tomography to detect coronary artery calcification (CAC) and aortic/iliac aneurysms; (ii) detection of atrial fibrillation (AF); (iii) brachial and ankle blood pressure measurements; and (iv) blood levels of cholesterol and hemoglobin A1c. Web based self booking and data management was used to reduce the administrative burden. RESULTS: Attendance rates were 64.9% (n = 678) and 63.0% (n = 640) for men and women, respectively. In total, 39.7% received a recommendation for medical preventive actions. Prevalence of aneurysms was 12.4% (95% confidence interval [CI] 9.9-14.9) in men and 1.1% (95% CI 0.3-1.9) in women, respectively (p < .001). A CAC score > 400 was found in 37.8% of men and 11.3% of women (p < .001), along with a significant increase in median CAC score with age (p = .03). Peripheral arterial disease was more prevalent in men (18.8%, 95% CI 15.8-21.8) than in women (11.2%, 95% CI 8.7-13.6). No significant differences between the sexes were found with regard to newly discovered AF (men 1.3%, women 0.5%), potential hypertension (men 9.7%, women 11.5%), hypercholesterolemia (men 0.9%, women 1.1%) or diabetes mellitus (men 2.1%, women 1.3%). CONCLUSION: Owing to the higher prevalence of severe conditions, such as aneurysms and CAC ≥ 400, screening for CVD seemed more prudent in men than women. The attendance rates were acceptable compared with other screening programs and the logistical structure of the screening program proved successful.
Authors: Nicole Lowres; Jake Olivier; Tze-Fan Chao; Shih-Ann Chen; Yi Chen; Axel Diederichsen; David A Fitzmaurice; Juan Jose Gomez-Doblas; Joseph Harbison; Jeff S Healey; F D Richard Hobbs; Femke Kaasenbrood; William Keen; Vivian W Lee; Jes S Lindholt; Gregory Y H Lip; Georges H Mairesse; Jonathan Mant; Julie W Martin; Enrique Martín-Rioboó; David D McManus; Javier Muñiz; Thomas Münzel; Juliet Nakamya; Lis Neubeck; Jessica J Orchard; Luis Ángel Pérula de Torres; Marco Proietti; F Russell Quinn; Andrea K Roalfe; Roopinder K Sandhu; Renate B Schnabel; Breda Smyth; Apurv Soni; Robert Tieleman; Jiguang Wang; Philipp S Wild; Bryan P Yan; Ben Freedman Journal: PLoS Med Date: 2019-09-25 Impact factor: 11.069
Authors: Jonathan R Weir-McCall; Kelley Branch; Maros Ferencik; Ron Blankstein; Andrew D Choi; Brian B Ghoshhajra; Kavitha Chinnaiyan; Purvi Parwani; Edward Nicol; Koen Nieman Journal: J Cardiovasc Comput Tomogr Date: 2020-10-01