| Literature DB >> 27889608 |
Jiaxuan Zhang1, Xiaofei Zhi1, Shiyu Shi2, Ran Tao1, Peisheng Chen1, Shiyu Sun1, Longjun Bian1, Zhangyan Xu2, Lilin Ma3.
Abstract
SPOCK1 encodes a Ca2+-binding matricellular glycoprotein which plays an oncogenic role in cancer cells. However, the role of SPOCK1 in the pathogenesis of colorectal cancer (CRC) has not been determined. Here, SPOCK1 was found higher expressed in CRC tissues than that of adjacent normal tissues. Furthermore, up-regulated expression of SPOCK1 in CRC patients was associated with tumor size and TNM stage. In addition, we observed that the depletion of SPOCK1 inhibited proliferation in vitro and tumorigenicity in vivo and promoted apoptosis in cell culture. Our data suggest that inactivation of PI3K/Akt signaling pathway was involved in down-regulation of SPOCK1-mediated suppression of tumor cell proliferation. These results suggest that SPOCK1 expression is correlated with malignant features of CRC and may serve as potential therapeutic and preventive strategies for CRC.Entities:
Keywords: Cell apoptosis; Cell proliferation; Colorectal cancer; PI3K/AKT pathway; SPOCK1
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Year: 2016 PMID： 27889608 DOI： 10.1016/j.bbrc.2016.11.126
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575