Timothy R Aksamit1, Anne E O'Donnell2, Alan Barker3, Kenneth N Olivier4, Kevin L Winthrop5, M Leigh Anne Daniels6, Margaret Johnson7, Edward Eden8, David Griffith9, Michael Knowles6, Mark Metersky10, Matthias Salathe11, Byron Thomashow12, Gregory Tino13, Gerard Turino14, Betsy Carretta15, Charles L Daley16. 1. Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN. Electronic address: aksamit.timothy@mayo.edu. 2. Division of Pulmonary, Critical Care, and Sleep Medicine, Georgetown University Hospital, Washington, DC. 3. Division of Pulmonary and Critical Care Medicine, Department of Medicine, Oregon Health & Science University, Portland, OR. 4. Cardiovascular and Pulmonary Branch, National Institute of Allergy and Infectious Diseases, Bethesda, MD. 5. Division of Infectious Disease, Department of Public Health and Preventive Medicine, Oregon Health & Science University, Portland, OR. 6. Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC. 7. Division of Pulmonary and Critical Care, Mayo Clinic Florida, Jacksonville, FL. 8. Department of Pulmonary, Critical Care, and Sleep Medicine, St. Luke's-Roosevelt Hospital Center at Columbia University, New York, NY. 9. Pulmonary Infectious Disease Section, University of Texas Health Science Center, Tyler, TX. 10. Division of Pulmonary and Critical Care Medicine, University of Connecticut School of Medicine, Farmington, CT. 11. Miller School of Medicine, University of Miami, Miami, FL. 12. Center for Chest Disease, Columbia University Medical Center-NY Presbyterian Hospital, New York, NY. 13. Department of Medicine, Penn Presbyterian Medical Center, Philadelphia, PA; University of Pennsylvania School of Medicine, Philadelphia, PA. 14. Department of Medicine, St. Luke's-Roosevelt Hospital Center at Columbia University, New York, NY. 15. Collaborative Studies Coordinating Center, University of North Carolina at Chapel Hill, Chapel Hill, NC. 16. Division of Mycobacterial and Respiratory Infections, National Jewish Health, Denver, CO.
Abstract
OBJECTIVES: We sought to describe the characteristics of adult patients with bronchiectasis enrolled in the US Bronchiectasis Research Registry (BRR). METHODS: The BRR is a database of patients with non-cystic-fibrosis bronchiectasis (NCFB) enrolled at 13 sites in the United States. Baseline demographic, spirometric, imaging, microbiological, and therapeutic data were entered into a central Internet-based database. Patients were subsequently analyzed by the presence of NTM. RESULTS: We enrolled 1,826 patients between 2008 and 2014. Patients were predominantly women (79%), white (89%), and never smokers (60%), with a mean age of 64 ± 14 years. Sixty-three percent of the patients had a history of NTM disease or NTM isolated at baseline evaluation for entry into the BRR. Patients with NTM were older, predominantly women, and had bronchiectasis diagnosed at a later age than those without NTM. Gastroesophageal reflux disease (GERD) was more common in those with NTM, whereas asthma, primary immunodeficiency, and primary ciliary dyskinesia were more common in those without NTM. Fifty-one percent of patients had spirometric evidence of airflow obstruction. Patients with NTM were more likely to have diffusely dilated airways and tree-in-bud abnormalities. Pseudomonas and Staphylococcus aureus isolates were cultured less commonly in patients with NTM. Bronchial hygiene measures were used more often in those with NTM, whereas antibiotics used for exacerbations, rotating oral antibiotics, steroid use, and inhaled bronchodilators were more commonly used in those without NTM. CONCLUSIONS: Adult patients with bronchiectasis enrolled in the US BRR are described, with differences noted in demographic, radiographic, microbiological, and treatment variables based on stratification of the presence of NTM.
OBJECTIVES: We sought to describe the characteristics of adult patients with bronchiectasis enrolled in the US Bronchiectasis Research Registry (BRR). METHODS: The BRR is a database of patients with non-cystic-fibrosis bronchiectasis (NCFB) enrolled at 13 sites in the United States. Baseline demographic, spirometric, imaging, microbiological, and therapeutic data were entered into a central Internet-based database. Patients were subsequently analyzed by the presence of NTM. RESULTS: We enrolled 1,826 patients between 2008 and 2014. Patients were predominantly women (79%), white (89%), and never smokers (60%), with a mean age of 64 ± 14 years. Sixty-three percent of the patients had a history of NTM disease or NTM isolated at baseline evaluation for entry into the BRR. Patients with NTM were older, predominantly women, and had bronchiectasis diagnosed at a later age than those without NTM. Gastroesophageal reflux disease (GERD) was more common in those with NTM, whereas asthma, primary immunodeficiency, and primary ciliary dyskinesia were more common in those without NTM. Fifty-one percent of patients had spirometric evidence of airflow obstruction. Patients with NTM were more likely to have diffusely dilated airways and tree-in-bud abnormalities. Pseudomonas and Staphylococcus aureus isolates were cultured less commonly in patients with NTM. Bronchial hygiene measures were used more often in those with NTM, whereas antibiotics used for exacerbations, rotating oral antibiotics, steroid use, and inhaled bronchodilators were more commonly used in those without NTM. CONCLUSIONS: Adult patients with bronchiectasis enrolled in the US BRR are described, with differences noted in demographic, radiographic, microbiological, and treatment variables based on stratification of the presence of NTM.
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