Ann-Christin Rößler1, Willi Kalender2, Daniel Kolditz2, Christian Steiding3, Veikko Ruth4, Caroline Preuss5, Sandra Christina Peter6, Barbara Brehm6, Matthias Hammon6, Rüdiger Schulz-Wendtland6, Evelyn Wenkel6. 1. Institute of Medical Physics, University of Erlangen-Nuremberg, Henkestrasse 91, Erlangen 91052, Germany. Electronic address: ann-christin.roessler@imp.uni-erlangen.de. 2. Institute of Medical Physics, University of Erlangen-Nuremberg, Henkestrasse 91, Erlangen 91052, Germany; AB-CT GmbH, Erlangen, Germany. 3. Institute of Medical Physics, University of Erlangen-Nuremberg, Henkestrasse 91, Erlangen 91052, Germany; AB-CT GmbH, Erlangen, Germany; Department of Radiology, University Hospital Erlangen, Erlangen, Germany. 4. Institute of Medical Physics, University of Erlangen-Nuremberg, Henkestrasse 91, Erlangen 91052, Germany. 5. Department of Gynecology and Obstetrics, University Hospital of Erlangen, Erlangen, Germany. 6. Department of Radiology, University Hospital Erlangen, Erlangen, Germany.
Abstract
RATIONALE AND OBJECTIVES: This study compared a novel photon-counting breast computed tomography (pcBCT) system with digital mammography (DM) and digital breast tomosynthesis (DBT) systems. For this reason, surgical specimens were examined with all three techniques and rated by three observers. MATERIALS AND METHODS: A total of 30 surgical specimens were investigated with DM, DBT, and pcBCT; the associated images were shown to three experienced radiologists. Findings (22 microcalcifications and 23 mass lesions) were recorded and compared to the results of the pathological examination. Sensitivity and specificity for detection of microcalcifications and lesions were calculated and displayed using receiver operating characteristic curves. RESULTS: Sensitivity for microcalcifications was 82% for DM, 70% for DBT, and 85% for pcBCT. Specificity for microcalcifications was 71% for DM, 75% for DBT, and 83% for pcBCT. Sensitivity for lesions was 45% for DM, 62% for DBT, and 65% for pcBCT. Specificity for lesions was 76% for DM, 62% for DBT, and 76% for pcBCT. CONCLUSIONS: pcBCT showed a comparable or superior performance compared to the clinically approved DM and DBT systems. Mass lesion detectability can be increased further by the use of contrast media.
RATIONALE AND OBJECTIVES: This study compared a novel photon-counting breast computed tomography (pcBCT) system with digital mammography (DM) and digital breast tomosynthesis (DBT) systems. For this reason, surgical specimens were examined with all three techniques and rated by three observers. MATERIALS AND METHODS: A total of 30 surgical specimens were investigated with DM, DBT, and pcBCT; the associated images were shown to three experienced radiologists. Findings (22 microcalcifications and 23 mass lesions) were recorded and compared to the results of the pathological examination. Sensitivity and specificity for detection of microcalcifications and lesions were calculated and displayed using receiver operating characteristic curves. RESULTS: Sensitivity for microcalcifications was 82% for DM, 70% for DBT, and 85% for pcBCT. Specificity for microcalcifications was 71% for DM, 75% for DBT, and 83% for pcBCT. Sensitivity for lesions was 45% for DM, 62% for DBT, and 65% for pcBCT. Specificity for lesions was 76% for DM, 62% for DBT, and 76% for pcBCT. CONCLUSIONS:pcBCT showed a comparable or superior performance compared to the clinically approved DM and DBT systems. Mass lesion detectability can be increased further by the use of contrast media.
Authors: Susanne Wienbeck; Johannes Uhlig; Uwe Fischer; Martin Hellriegel; Eva von Fintel; Dietrich Kulenkampff; Alexey Surov; Joachim Lotz; Christina Perske Journal: Medicine (Baltimore) Date: 2019-09 Impact factor: 1.817