Hui Liu1, Shouling Wu2, Yun Li3, Lixia Sun4, Zhe Huang5, Liming Lin6, Yan Liu6, Chunpeng Ji6, Hualing Zhao7, Chunhui Li7, Lu Song7, Hongliang Cong8. 1. Department of Cardiology, Tianjin Chest Hospital, Graduate School of Tianjin Medical University, Tianjin 300051, China; Department of Infectious Disease, Kailuan Hospital, Tangshan 063000, China. 2. Department of Cardiology, Kailuan Hospital, Tangshan 063000, China. Electronic address: drwusl@163.com. 3. School of Public Heath, North China University of Science and Technology, Tangshan 063000, China. 4. Department of Cardiology, Tianjin Chest Hospital, Graduate School of Tianjin Medical University, Tianjin 300051, China; Department of Emergency, The Affiliated Hospital of North China University of Science and Technology, Tangshan 063000, China. 5. Department of Cardiology, Tianjin Chest Hospital, Graduate School of Tianjin Medical University, Tianjin 300051, China; Department of Cardiology, Kailuan Hospital, Tangshan 063000, China. 6. Department of Cardiology, Kailuan Hospital, Tangshan 063000, China. 7. Department of Cardiology, Kailuan Hospital, Tangshan 063000, China; Graduate School, North China University of Science and Technology 063000, Tangshan, China. 8. Department of Cardiology, Tianjin Chest Hospital, Graduate School of Tianjin Medical University, Tianjin 300051, China. Electronic address: hongliangcong@126.com.
Abstract
AIMS: To investigate the association between body-mass index and mortality in Chinese adults T2DM. METHODS: 11,449 participants of Kailuan Study with T2DM were included in this prospective cohort study. All-cause mortality was calculated using Kaplan-Meier analysis. Cox proportional hazards analysis was used to estimate the association between BMI and mortality. RESULTS: During a mean follow-up period of 7.25±1.42years, 1254 deaths occurred. The number of deaths of the underweight, normal weight, overweight, and obese group was 23, 389, 557, and 285; the corresponding mortality was 25.0%, 13.4%, 10.3%, and 9.4%, respectively. The obese group had the lowest all-cause mortality rate (log-rank chi-square=48.430, P<0.001). After adjusting for age, sex, fasting blood glucose, smoking status, systolic blood pressure, history of hypertension, stroke, cancer and myocardial infarction, compared with the normal weight group, Multivariate Cox proportional hazard regression analysis showed that HR (95% CI) of all-cause mortality in the underweight, overweight, and obese group was 1.497 (0.962, 2.330), 0.833 (0.728, 0.952), and 0.809 (0.690, 0.949). After stratifying for age tertiles, this trend remained. CONCLUSIONS: In T2DM patients in north China, the risk for all-cause mortality was lower in the overweight and the obese groups than those in the normal weight and the underweight groups.
AIMS: To investigate the association between body-mass index and mortality in Chinese adults T2DM. METHODS: 11,449 participants of Kailuan Study with T2DM were included in this prospective cohort study. All-cause mortality was calculated using Kaplan-Meier analysis. Cox proportional hazards analysis was used to estimate the association between BMI and mortality. RESULTS: During a mean follow-up period of 7.25±1.42years, 1254 deaths occurred. The number of deaths of the underweight, normal weight, overweight, and obese group was 23, 389, 557, and 285; the corresponding mortality was 25.0%, 13.4%, 10.3%, and 9.4%, respectively. The obese group had the lowest all-cause mortality rate (log-rank chi-square=48.430, P<0.001). After adjusting for age, sex, fasting blood glucose, smoking status, systolic blood pressure, history of hypertension, stroke, cancer and myocardial infarction, compared with the normal weight group, Multivariate Cox proportional hazard regression analysis showed that HR (95% CI) of all-cause mortality in the underweight, overweight, and obese group was 1.497 (0.962, 2.330), 0.833 (0.728, 0.952), and 0.809 (0.690, 0.949). After stratifying for age tertiles, this trend remained. CONCLUSIONS: In T2DM patients in north China, the risk for all-cause mortality was lower in the overweight and the obese groups than those in the normal weight and the underweight groups.
Authors: Jun Jie Benjamin Seng; Amelia Yuting Monteiro; Yu Heng Kwan; Sueziani Binte Zainudin; Chuen Seng Tan; Julian Thumboo; Lian Leng Low Journal: BMC Med Res Methodol Date: 2021-03-11 Impact factor: 4.615