Literature DB >> 27886989

U.S. Department of Defense Multiple-Parameter Biodosimetry Network.

William F Blakely1, Alexander Romanyukha2, Selena M Hayes2, Ricardo A Reyes3, H Michael Stewart4, Matthew H Hoefer5, Anthony Williams2, Thad Sharp2, L Andrew Huff5.   

Abstract

The U.S. Department of Defense (USDOD) service members are at risk of exposure to ionizing radiation due to radiation accidents, terrorist attacks and national defense activities. The use of biodosimetry is a standard of care for the triage and treatment of radiation injuries. Resources and procedures need to be established to implement a multiple-parameter biodosimetry system coupled with expert medial guidance to provide an integrated radiation diagnostic system to meet USDOD requirements. Current USDOD biodosimetry capabilities were identified and recommendations to fill the identified gaps are provided. A USDOD Multi-parametric Biodosimetry Network, based on the expertise that resides at the Armed Forces Radiobiology Research Institute and the Naval Dosimetry Center, was designed. This network based on the use of multiple biodosimetry modalities would provide diagnostic and triage capabilities needed to meet USDOD requirements. These are not available with sufficient capacity elsewhere but could be needed urgently after a major radiological/nuclear event. Published by Oxford University Press 2016. This work is written by (a) US Government employee(s) and is in the public domain in the US.

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Year:  2016        PMID: 27886989     DOI: 10.1093/rpd/ncw295

Source DB:  PubMed          Journal:  Radiat Prot Dosimetry        ISSN: 0144-8420            Impact factor:   0.972


  7 in total

1.  Biodosimetry: A Future Tool for Medical Management of Radiological Emergencies.

Authors:  Mary T Sproull; Kevin A Camphausen; Gregory D Koblentz
Journal:  Health Secur       Date:  2017-12-01

Review 2.  Nuclear and Radiological Emergencies: Biological Effects, Countermeasures and Biodosimetry.

Authors:  Elena Obrador; Rosario Salvador-Palmer; Juan I Villaescusa; Eduardo Gallego; Blanca Pellicer; José M Estrela; Alegría Montoro
Journal:  Antioxidants (Basel)       Date:  2022-05-31

3.  Automatic reagent handling and assay processing of human biospecimens inside a transportation container for a medical disaster response against radiation.

Authors:  Adam R Akkad; Jian Gu; Brett Duane; Alan Norquist; David J Brenner; Adarsh Ramakumar; Frederic Zenhausern
Journal:  PLoS One       Date:  2022-05-20       Impact factor: 3.752

4.  Dose and Dose-Rate Effects in a Mouse Model of Internal Exposure from 137Cs. Part 2: Integration of Gamma-H2AX and Gene Expression Biomarkers for Retrospective Radiation Biodosimetry.

Authors:  Igor Shuryak; Shanaz A Ghandhi; Helen C Turner; Waylon Weber; Dunstana Melo; Sally A Amundson; David J Brenner
Journal:  Radiat Res       Date:  2020-11-01       Impact factor: 2.841

5.  Transportation container for pre-processing cytogenetic assays in radiation accidents.

Authors:  Jian Gu; Brett Duane; Mikhail Repin; David J Brenner; Frederic Zenhausern
Journal:  Sci Rep       Date:  2021-05-17       Impact factor: 4.996

6.  Machine learning methodology for high throughput personalized neutron dose reconstruction in mixed neutron + photon exposures.

Authors:  Igor Shuryak; Helen C Turner; Monica Pujol-Canadell; Jay R Perrier; Guy Garty; David J Brenner
Journal:  Sci Rep       Date:  2021-02-17       Impact factor: 4.379

7.  Transcriptomic responses in mouse blood during the first week after in vivo gamma irradiation.

Authors:  Sunirmal Paul; Norman J Kleiman; Sally A Amundson
Journal:  Sci Rep       Date:  2019-12-04       Impact factor: 4.379

  7 in total

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