Literature DB >> 27886301

Palladium-mediated in situ synthesis of an anticancer agent.

Eugenio Indrigo1, Jessica Clavadetscher1, Sunay V Chankeshwara1, Annamaria Lilienkampf1, Mark Bradley1.   

Abstract

As a novel prodrug activation strategy Pd(0) nanoparticles, entrapped within a modular polymeric support, were used in cell culture, to synthesise the anticancer agent PP-121 from two non-toxic precursors, thereby inducing cell death in the first example of in situ mediated drug synthesis.

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Year:  2016        PMID： 27886301     DOI： 10.1039/c6cc08666g

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  7 in total

1.  Ruthenium-Catalyzed Redox Isomerizations inside Living Cells.

Authors:  Cristian Vidal; María Tomás-Gamasa; Alejandro Gutiérrez-González; José L Mascareñas
Journal:  J Am Chem Soc       Date:  2019-03-22       Impact factor: 15.419

2.  Synthetic prodrug design enables biocatalytic activation in mice to elicit tumor growth suppression.

Authors:  Igor Nasibullin; Ivan Smirnov; Peni Ahmadi; Kenward Vong; Almira Kurbangalieva; Katsunori Tanaka
Journal:  Nat Commun       Date:  2022-01-10       Impact factor: 14.919

3.  Bioorthogonal release of anticancer drugs via gold-triggered 2-alkynylbenzamide cyclization.

Authors:  Kenward Vong; Tomoya Yamamoto; Tsung-Che Chang; Katsunori Tanaka
Journal:  Chem Sci       Date:  2020-09-02       Impact factor: 9.825

4.  Catalytically Active Single-Chain Polymeric Nanoparticles: Exploring Their Functions in Complex Biological Media.

Authors:  Yiliu Liu; Sílvia Pujals; Patrick J M Stals; Thomas Paulöhrl; Stanislav I Presolski; E W Meijer; Lorenzo Albertazzi; Anja R A Palmans
Journal:  J Am Chem Soc       Date:  2018-02-23       Impact factor: 15.419

Review 5.  Palladium-based nanomaterials for cancer imaging and therapy.

Authors:  Yongchun Liu; Jingchao Li; Mei Chen; Xiaolan Chen; Nanfeng Zheng
Journal:  Theranostics       Date:  2020-08-08       Impact factor: 11.556

6.  Intracellular Antioxidant Activity of Biocompatible Citrate-Capped Palladium Nanozymes.

Authors:  Mauro Moglianetti; Deborah Pedone; Gayatri Udayan; Saverio Francesco Retta; Doriana Debellis; Roberto Marotta; Antonio Turco; Simona Rella; Cosimino Malitesta; Giulia Bonacucina; Elisa De Luca; Pier Paolo Pompa
Journal:  Nanomaterials (Basel)       Date:  2020-01-03       Impact factor: 5.076

7.  "Close-to-Release": Spontaneous Bioorthogonal Uncaging Resulting from Ring-Closing Metathesis.

Authors:  Valerio Sabatino; Johannes G Rebelein; Thomas R Ward
Journal:  J Am Chem Soc       Date:  2019-09-19       Impact factor: 15.419
  7 in total

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