| Literature DB >> 27884843 |
T Lawrence1, A Helmy2,3, O Bouamra1, M Woodford1, F Lecky4, P J Hutchinson2,3.
Abstract
OBJECTIVES: To provide a comprehensive assessment of the management of traumatic brain injury (TBI) relating to epidemiology, complications and standardised mortality across specialist units.Entities:
Keywords: ACCIDENT & EMERGENCY MEDICINE; NEUROSURGERY; TRAUMA MANAGEMENT
Mesh:
Year: 2016 PMID: 27884843 PMCID: PMC5168492 DOI: 10.1136/bmjopen-2016-012197
Source DB: PubMed Journal: BMJ Open ISSN: 2044-6055 Impact factor: 2.692
Figure 1Flow chart delineating the derivation of the TBI cohort studied. TARN, Trauma Audit and Research Network; TBI, traumatic brain injury.
Figure 2Proportion of all patients with TBI by age and mechanism of injury. RTI, road traffic collision; TBI, traumatic brain injury.
Figure 3Proportion of patients with severe TBI (TBI in combination with GCS≤8) by age and mechanism of injury. RTI, road traffic collision.
Hospital transfer, airway management and length of stay
| Category | Group | Severe TBI | Moderate TBI | Mild TBI | GCS not recorded | Total |
|---|---|---|---|---|---|---|
| Total number of patients | 3915 | 899 | 10 266 | 742 | 15 822 | |
| Mode of arrival | Ambulance | 2504 (71.6%) | 662 (83.8%) | 6951 (76.6%) | 51 (11.1%) | 10 168 (73.5%) |
| Car | 3 (0.1%) | 1 (0.1%) | 65 (0.7%) | 7 (1.5%) | 76 (0.5%) | |
| Helicopter | 660 (18.9%) | 27 (3.4%) | 309 (3.4%) | 0 (0%) | 996 (7.2%) | |
| Other | 1 (0%) | 1 (0.1%) | 38 (0.4%) | 1 (0.2%) | 41 (0.3%) | |
| Unknown | 329 (9.4%) | 99 (12.5%) | 1714 (18.9%) | 402 (87.2%) | 2544 (18.4%) | |
| Transfer status (all patients), n=15 820 | Direct admission to neurocentre | 2353 (60.1%) | 365 (40.6%) | 3374 (32.9%) | 167 (22.5%) | 6259 (39.6%) |
| Transfer into neurocentre | 945 (24.1%) | 181 (20.1%) | 2298 (22.4%) | 259 (34.9%) | 3683 (23.3%) | |
| No neurocentre visit | 617 (15.8%) | 353 (39.3%) | 4594 (44.7%) | 316 (42.6%) | 5880 (37.2%) | |
| Hours to arrival at neurocentre | 0–4 | 2225 (67.5%) | 303 (55.5%) | 2621 (46.2%) | 46 (10.8%) | 5195 (52.3%) |
| 4–12 | 438 (13.3%) | 64 (11.7%) | 733 (12.9%) | 19 (4.5%) | 1254 (12.6%) | |
| 12–24 | 57 (1.7%) | 21 (3.8%) | 252 (4.4%) | 8 (1.9%) | 338 (3.4%) | |
| 24–48 | 32 (1%) | 9 (1.6%) | 147 (2.6%) | 6 (1.4%) | 194 (2%) | |
| 48–72 | 3 (0.1%) | 1 (0.2%) | 73 (1.3%) | 1 (0.2%) | 78 (0.8%) | |
| 72+ | 23 (0.7%) | 13 (2.4%) | 249 (4.4%) | 16 (3.8%) | 301 (3%) | |
| Unknown | 520 (15.8%) | 135 (24.7%) | 1597 (28.2%) | 330 (77.5%) | 2582 (26%) | |
| Median length of stay (days) (IQR) n=15 820 | 12 (3–33) | 11 (5–24) | 9 (5–18) | 10 (5–21) | 9 (4–21) | |
| Intubation location (direct admissions, n=13 824) | Prehospital | 765 (21.9%) | 0 (0%) | 0 (0%) | 0 (0%) | 765 (5.5%) |
| ED | 2236 (63.9%) | 0 (0%) | 0 (0%) | 0 (0%) | 2236 (16.2%) | |
| Critical care | 142 (4.1%) | 71 (9%) | 257 (2.8%) | 21 (4.6%) | 491 (3.6%) | |
| Ward | 0 (0%) | 0 (0%) | 4 (0%) | 2 (0.4%) | 6 (0%) | |
| Not intubated | 354 (10.1%) | 719 (91%) | 8815 (97.1%) | 438 (95%) | 10 326 (74.7%) | |
ED, emergency department; GCS, Glasgow Coma Score; TBI, traumatic brain injury.
Median time to CT scanning, craniotomy and ICP monitoring from hospital arrival/incident*
| TBI severity | Measured from | Category | n† | Median hours | IQR lower bound | IQR upper bound |
|---|---|---|---|---|---|---|
| Severe TBI | Arrival time | CT | 3307 | 0.5 | 0.3 | 0.8 |
| Craniotomy | 457 | 2.6 | 1.6 | 10.1 | ||
| ICP monitoring | 411 | 3.1 | 1.8 | 7.4 | ||
| Incident time | CT | 3565 | 2.0 | 1.5 | 3.2 | |
| Craniotomy (direct) | 423 | 4.0 | 2.9 | 17.2 | ||
| Craniotomy (transfer) | 262 | 7.3 | 5.3 | 19.0 | ||
| ICP monitoring | 571 | 5.8 | 3.5 | 11.3 | ||
| Moderate TBI | Arrival time | CT | 766 | 0.9 | 0.5 | 1.9 |
| Craniotomy | 45 | 8.6 | 2.8 | 47.9 | ||
| ICP monitoring | 16 | 8.4 | 2.7 | 47.9 | ||
| Incident time | CT | 751 | 2.5 | 1.8 | 5.5 | |
| Craniotomy (direct) | 42 | 15.8 | 5.3 | 65.8 | ||
| Craniotomy (transfer) | 24 | 38.3 | 9.7 | 226.0 | ||
| ICP monitoring | 19 | 8.6 | 6.1 | 48.8 | ||
| Mild TBI | Arrival time | CT | 8740 | 1.7 | 0.7 | 3.3 |
| Craniotomy | 218 | 19.2 | 6.6 | 97.3 | ||
| ICP monitoring | 41 | 11.6 | 5.8 | 28.6 | ||
| Incident time | CT | 8173 | 3.7 | 2.3 | 8.6 | |
| Craniotomy (direct) | 170 | 21.4 | 7.4 | 119.2 | ||
| Craniotomy (transfer) | 320 | 53.2 | 16.3 | 240.6 | ||
| ICP monitoring | 69 | 18.3 | 8.4 | 38.0 | ||
| GCS not recorded | Arrival time | CT | 367 | 3.5 | 1.4 | 16.5 |
| Craniotomy | 14 | 15.4 | 8.5 | 36.8 | ||
| ICP monitoring | 2 | 10.1 | 0.0 | 0.0 | ||
| Incident time | CT | 202 | 8.5 | 2.4 | 36.6 | |
| Craniotomy (direct) | 4 | 189.1 | 0.0 | 0.0 | ||
| Craniotomy (transfer) | 19 | 40.0 | 12.4 | 560.3 | ||
| ICP monitoring | 7 | 11.3 | 10.0 | 11.7 |
*Hospital arrival time is recorded in almost 100% of cases; incident time is recorded in ∼75% of cases. Intervals measured from incident time include patients that are transferred between hospitals; those measured from arrival time only include patients admitted directly from the scene of injury.
†n values relate to the number of observations in each cohort. For example, 3307 patients with a severe TBI underwent CT scanning and have their arrival and CT scan dates and times recorded.
GCS, Glasgow Coma Score; TBI, traumatic brain injury.
Inpatient complications stratified by severity of injury
| Complication | Severe TBI | Moderate TBI | Mild TBI | GCS not recorded | Total |
|---|---|---|---|---|---|
| Aspiration | 63 (1.5%) | 8 (0.9%) | 48 (0.5%) | 5 (0.6%) | 124 (0.8%) |
| Bronchopneumonia | 203 (4.9%) | 32 (3.4%) | 209 (2%) | 17 (2.2%) | 461 (2.8%) |
| Pleural effusion | 84 (2%) | 9 (1%) | 68 (0.7%) | 12 (1.6%) | 173 (1.1%) |
| Seizure in hospital | 119 (2.9%) | 22 (2.4%) | 141 (1.4%) | 15 (1.9%) | 297 (1.8%) |
| Sepsis | 129 (3.1%) | 9 (1%) | 107 (1%) | 13 (1.7%) | 258 (1.6%) |
| Other | 624 (15%) | 106 (11.4%) | 836 (8%) | 88 (11.4%) | 1654 (10.1%) |
| No complications recorded | 2944 (70.7%) | 744 (80%) | 9027 (86.5%) | 623 (80.6%) | 13 338 (81.8%) |
GCS, Glasgow Coma Score; TBI, traumatic brain injury.
Figure 4Funnel plot showing the Wsn for neurosurgical units in England and Wales between April 2014 and June 2015. Wsn, W scores derived using the Ps14 multivariate logistic regression model.