Chao Xuan1, Zhen-Fang Liu2, Qing Wang1, Fen-Fen Guo3, Xiao Zhang4, Guo-Wei He5, Li-Min Lun6. 1. Department of Clinical Laboratory, The Affiliated Hospital of Qingdao University, Qingdao, China. 2. Department of Emergency Medicine, The Affiliated Hospital of Qingdao University, Qingdao, China. 3. Department of Clinical Laboratory, Qingdao Women and Children's Hospital, Qingdao, China. 4. Department of Anesthesiology, The Affiliated Hospital of Qingdao University, Qingdao, China. 5. Department of Surgery, TEDA International Cardiovascular Hospital, Tianjin, China; Department of Cardiovascular Surgery, The Affiliated Hospital of Hangzhou Normal University and Zhejiang University, Hangzhou, China; Department of Surgery, Oregon Health and Science University, Portland, OR, United States. 6. Department of Clinical Laboratory, The Affiliated Hospital of Qingdao University, Qingdao, China. Electronic address: lunlmqd@163.com.
Abstract
BACKGROUND: Asymmetric dimethylarginine (ADMA) has been associated with an increased risk of cardiovascular disease. We investigated the role of serum ADMA concentrations in early-onset coronary artery disease (EOCAD). METHODS: Candidates for coronary artery angiography (age<50y for men and <55y for women) who met the inclusion criteria were enrolled in this study. Serum concentrations of ADMA were determined using ELISA. Severity of coronary atherosclerosis was estimated by number of diseased vessels. RESULTS: A total of 601 subjects (286 with EOCAD patients and 315 controls) were included in the study. ADMA concentrations were found to be significantly higher in the EOCAD group (0.480±0.110μmol/l) than in the control group (0.457±0.091, P=0.007). ADMA concentrations significantly increased with the number of diseased vessels (P<0.001). In addition, serum ADMA concentrations were affected by diabetes mellitus and smoking status, and were positively correlated with serum creatinine and body mass index (BMI). CONCLUSIONS: Our results show that serum ADMA concentrations were associated with the presence and severity of EOCAD, suggesting that ADMA may be involved in the progression of EOCAD.
BACKGROUND: Asymmetric dimethylarginine (ADMA) has been associated with an increased risk of cardiovascular disease. We investigated the role of serum ADMA concentrations in early-onset coronary artery disease (EOCAD). METHODS: Candidates for coronary artery angiography (age<50y for men and <55y for women) who met the inclusion criteria were enrolled in this study. Serum concentrations of ADMA were determined using ELISA. Severity of coronary atherosclerosis was estimated by number of diseased vessels. RESULTS: A total of 601 subjects (286 with EOCAD patients and 315 controls) were included in the study. ADMA concentrations were found to be significantly higher in the EOCAD group (0.480±0.110μmol/l) than in the control group (0.457±0.091, P=0.007). ADMA concentrations significantly increased with the number of diseased vessels (P<0.001). In addition, serum ADMA concentrations were affected by diabetes mellitus and smoking status, and were positively correlated with serum creatinine and body mass index (BMI). CONCLUSIONS: Our results show that serum ADMA concentrations were associated with the presence and severity of EOCAD, suggesting that ADMA may be involved in the progression of EOCAD.
Authors: Patricia Siques; Julio Brito; Edzard Schwedhelm; Eduardo Pena; Fabiola León-Velarde; Juan José De La Cruz; Rainer H Böger; Juliane Hannemann Journal: Front Physiol Date: 2019-05-27 Impact factor: 4.566