Xiaoyu Hu1, Ellie H Jhun1, Yingwei Yao2,3, Ying He1,4, Robert E Molokie1,4,5,6, Diana J Wilkie2,3,4, Zaijie J Wang1,4. 1. Department of Biopharmaceutical Sciences, University of Illinois at Chicago College of Pharmacy, Chicago, IL, USA. 2. Department of Biobehavioral Health Science, University of Illinois at Chicago College of Nursing, Chicago, IL, USA. 3. Department of Biobehavioral Nursing Science, University of Florida College of Nursing, Gainesville, FL, USA. 4. Comprehensive Sickle Cell Center, University of Illinois at Chicago, IL, USA. 5. Jesse Brown Veteran's Administration Medical Center, Chicago, IL, USA. 6. Division of Hematology/Oncology, University of Illinois at Chicago College of Medicine, Chicago, IL, USA.
Abstract
AIM: Pain is prevalent in sickle cell disease (SCD) patients who display great heterogeneity in pain severity and frequency. Hypothesizing that inflammatory factors are involved in the pathogenesis of SCD pain, we focused on the IL1A C/T polymorphism rs1800587 that is an SNP located in a cis-transcriptional regulatory region. METHODS: We genotyped IL1A rs1800587 and performed association studies with phenotype data obtained by a multidimensional pain assessment tool using the PAINReportIt® Questionnaire. RESULTS: Each T allele was associated with a 3.9 increase in composite pain index score (p = 0.04) as determined by multiple linear regression. CONCLUSION: IL1A rs1800587 may influence chronic pain in SCD.
AIM: Pain is prevalent in sickle cell disease (SCD) patients who display great heterogeneity in pain severity and frequency. Hypothesizing that inflammatory factors are involved in the pathogenesis of SCD pain, we focused on the IL1A C/T polymorphism rs1800587 that is an SNP located in a cis-transcriptional regulatory region. METHODS: We genotyped IL1Ars1800587 and performed association studies with phenotype data obtained by a multidimensional pain assessment tool using the PAINReportIt® Questionnaire. RESULTS: Each T allele was associated with a 3.9 increase in composite pain index score (p = 0.04) as determined by multiple linear regression. CONCLUSION:IL1Ars1800587 may influence chronic pain in SCD.
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