Literature DB >> 2788149

Presence of epidermal growth factor in human tears.

Y Ohashi1, M Motokura, Y Kinoshita, T Mano, H Watanabe, S Kinoshita, R Manabe, K Oshiden, C Yanaihara.   

Abstract

Epidermal growth factor (EGF) is a polypeptide that stimulates the growth of various tissues, including the cornea. The presence of EGF in tears from normal volunteers and in aqueous humor from cataract patients was investigated via human EGF (hEGF)-specific radioimmunoassay. Immunoreactive hEGF was found to be present at similar concentrations in both reflex (ranging from 0.7 to 8.1 ng/ml) and non-reflex tears (ranging from 1.9 to 9.7 ng/ml), but was undetectable in aqueous humor. Immunoreactive EGF in human tears was indistinguishable immunologically, biologically and biochemically from urine EGF and standard hEGF.

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Year:  1989        PMID： 2788149

Source DB:  PubMed          Journal:  Invest Ophthalmol Vis Sci        ISSN： 0146-0404            Impact factor:   4.799


  39 in total

Review 1.  Immunology of corneal transplantation.

Authors:  W H Constad; K Taraschanskiy
Journal:  Clin Rev Allergy Immunol       Date:  2001-04       Impact factor: 8.667

2.  Influence of topical human epidermal growth factor on postkeratoplasty re-epithelialisation.

Authors:  M M Dellaert; T A Casey; S Wiffen; J Gordon; P Johnson; A J Geerards; W J Rijneveld; L Remeijer; P G Mulder; W H Beekhuis
Journal:  Br J Ophthalmol       Date:  1997-05       Impact factor: 4.638

3.  Using synthesized onion lachrymatory factor to measure age-related decreases in reflex-tear secretion and ocular-surface sensation.

Authors:  Hisayo Higashihara; Norihiko Yokoi; Morihiro Aoyagi; Nobuaki Tsuge; Shinsuke Imai; Shigeru Kinoshita
Journal:  Jpn J Ophthalmol       Date:  2010-06-25       Impact factor: 2.447

Review 4.  Novel strategies for anterior segment ocular drug delivery.

Authors:  Kishore Cholkar; Sulabh P Patel; Aswani Dutt Vadlapudi; Ashim K Mitra
Journal:  J Ocul Pharmacol Ther       Date:  2012-12-05       Impact factor: 2.671

5.  Frequent expression of genes for receptor tyrosine kinases and their ligands in human pancreatic cancer cells.

Authors:  T Oikawa; J Hitomi; A Kono; E Kaneko; K Yamaguchi
Journal:  Int J Pancreatol       Date:  1995-08

6.  Distribution of epidermal growth factor in rat ocular and periocular tissues.

Authors:  H Watanabe; Y Ohashi; S Kinoshita; R Manabe; K Ohshiden
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  1993-04       Impact factor: 3.117

7.  Next-generation analysis of cataracts: determining knowledge driven gene-gene interactions using Biofilter, and gene-environment interactions using the PhenX Toolkit.

Authors:  Sarah A Pendergrass; Shefali S Verma; Emily R Holzinger; Carrie B Moore; John Wallace; Scott M Dudek; Wayne Huggins; Terrie Kitchner; Carol Waudby; Richard Berg; Catherine A McCarty; Marylyn D Ritchie
Journal:  Pac Symp Biocomput       Date:  2013

Review 8.  [Dry eye disease as a complex dysregulation of the functional anatomy of the ocular surface. New concepts for understanding dry eye disease].

Authors:  E Knop; N Knop; H Brewitt
Journal:  Ophthalmologe       Date:  2003-11       Impact factor: 1.059

9.  Elucidation of apoptosis induced by serum deprivation in cultured conjunctival epithelial cells.

Authors:  A Higuchi; S Shimmura; T Takeuchi; M Suematsu; K Tsubota
Journal:  Br J Ophthalmol       Date:  2006-03-10       Impact factor: 4.638

10.  Albumin as a tear supplement in the treatment of severe dry eye.

Authors:  S Shimmura; R Ueno; Y Matsumoto; E Goto; A Higuchi; J Shimazaki; K Tsubota
Journal:  Br J Ophthalmol       Date:  2003-10       Impact factor: 4.638
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