Literature DB >> 2788129

Mouse bone marrow-derived IL-3-dependent mast cells and autonomous sublines produce IL-6.

L Hültner1, H Szöts, M Welle, J Van Snick, J Moeller, P Dörmer.   

Abstract

This study deals with the question of whether mouse bone marrow-derived mast cells are able to produce interleukin-6 (IL-6) in vitro. For this purpose, a panel of primary mast cell clones from limiting-dilution microcultures, of permanent IL-3-dependent mast cell lines and autonomous malignant sublines, was screened. All of these lines were found to produce growth factor activity for IL-6-dependent mouse hybridoma cells (7TD1), which could be completely neutralized by the monoclonal anti-IL-6-antibody 6B4. Transcriptional activity of the IL-6 gene was demonstrated in both IL-3-dependent mast cells and autonomous sublines using a mouse IL-6-specific cDNA probe.

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Year:  1989        PMID： 2788129      PMCID： PMC1385361     

Source DB:  PubMed          Journal:  Immunology        ISSN： 0019-2805            Impact factor:   7.397


  34 in total

Review 1.  Mediation of local homeostasis and inflammation by leukotrienes and other mast cell-dependent compounds.

Authors:  R A Lewis; K F Austen
Journal:  Nature       Date:  1981 Sep 10-16       Impact factor: 49.962

2.  Immune reactions in mucous membranes. I. Intestinal mast cell response during helminth expulsion in the rat.

Authors:  H R Miller; W F Jarrett
Journal:  Immunology       Date:  1971-03       Impact factor: 7.397

3.  Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.

Authors:  T Mosmann
Journal:  J Immunol Methods       Date:  1983-12-16       Impact factor: 2.303

4.  Mast cells at sites of cartilage erosion in the rheumatoid joint.

Authors:  M Bromley; W D Fisher; D E Woolley
Journal:  Ann Rheum Dis       Date:  1984-02       Impact factor: 19.103

5.  Induction of a 26-kDa-protein mRNA in human cells treated with an interleukin-1-related, leukocyte-derived factor.

Authors:  J Content; L De Wit; P Poupart; G Opdenakker; J Van Damme; A Billiau
Journal:  Eur J Biochem       Date:  1985-10-15

6.  Characterization of a murine lymphokine distinct from interleukin 2 and interleukin 3 (IL-3) possessing a T-cell growth factor activity and a mast-cell growth factor activity that synergizes with IL-3.

Authors:  C A Smith; D M Rennick
Journal:  Proc Natl Acad Sci U S A       Date:  1986-03       Impact factor: 11.205

7.  Delayed expulsion of adult Trichinella spiralis by mast cell-deficient W/Wv mice.

Authors:  T Y Ha; N D Reed; P K Crowle
Journal:  Infect Immun       Date:  1983-07       Impact factor: 3.441

8.  Interleukin 3-dependent hematopoietic progenitor cell lines.

Authors:  J S Greenberger; R J Eckner; M Sakakeeny; P Marks; D Reid; G Nabel; A Hapel; J N Ihle; K C Humphries
Journal:  Fed Proc       Date:  1983-07

9.  Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease.

Authors:  J M Chirgwin; A E Przybyla; R J MacDonald; W J Rutter
Journal:  Biochemistry       Date:  1979-11-27       Impact factor: 3.162

10.  Gut mucosal mast cells. Origin, traffic, and differentiation.

Authors:  D Guy-Grand; M Dy; G Luffau; P Vassalli
Journal:  J Exp Med       Date:  1984-07-01       Impact factor: 14.307
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  11 in total

1.  Contribution of Fibroblast and Mast Cell (Afferent) and Tumor (Efferent) IL-6 Effects within the Tumor Microenvironment.

Authors:  Honor J Hugo; Stephanie Lebret; Eva Tomaskovic-Crook; Nuzhat Ahmed; Tony Blick; Donald F Newgreen; Erik W Thompson; M Leigh Ackland
Journal:  Cancer Microenviron       Date:  2012-02-08

Review 2.  Mast cells as sources of cytokines, chemokines, and growth factors.

Authors:  Kaori Mukai; Mindy Tsai; Hirohisa Saito; Stephen J Galli
Journal:  Immunol Rev       Date:  2018-03       Impact factor: 12.988

3.  PTEN deficiency in mast cells causes a mastocytosis-like proliferative disease that heightens allergic responses and vascular permeability.

Authors:  Yasuko Furumoto; Nicolas Charles; Ana Olivera; Wai Hang Leung; Sandra Dillahunt; Jennifer L Sargent; Kevin Tinsley; Sandra Odom; Eric Scott; Todd M Wilson; Kamran Ghoreschi; Manfred Kneilling; Mei Chen; David M Lee; Silvia Bolland; Juan Rivera
Journal:  Blood       Date:  2011-09-16       Impact factor: 22.113

4.  Chronic resuscitation after trauma-hemorrhage and acute fluid replacement improves hepatocellular function and cardiac output.

Authors:  D E Remmers; P Wang; W G Cioffi; K I Bland; I H Chaudry
Journal:  Ann Surg       Date:  1998-01       Impact factor: 12.969

5.  Kinetics of interleukin-6 production after experimental infection of mice with Schistosoma mansoni.

Authors:  R M Khalil; L Hültner; R Mailhammer; A Luz; J Moeller; A A Mohamed; S Omran; P Dörmer
Journal:  Immunology       Date:  1996-10       Impact factor: 7.397

6.  Schistosoma mansoni infection in mice augments the capacity for interleukin 3 (IL-3) and IL-9 production and concurrently enlarges progenitor pools for mast cells and granulocytes-macrophages.

Authors:  R M Khalil; A Luz; R Mailhammer; J Moeller; A A Mohamed; S Omran; P Dörmer; L Hültner
Journal:  Infect Immun       Date:  1996-12       Impact factor: 3.441

7.  Interleukin 6 promotes murine lupus in NZB/NZW F1 mice.

Authors:  B K Finck; B Chan; D Wofsy
Journal:  J Clin Invest       Date:  1994-08       Impact factor: 14.808

8.  Aphidicolin-induced proliferative arrest of murine mast cells: morphological and biochemical changes are not accompanied by alterations in cytokine gene induction.

Authors:  J J Costa; J M Keffer; J P Goff; D D Metcalfe
Journal:  Immunology       Date:  1992-07       Impact factor: 7.397

9.  Mast cell IL-6 improves survival from Klebsiella pneumonia and sepsis by enhancing neutrophil killing.

Authors:  Rachel E Sutherland; Joanna S Olsen; Andrew McKinstry; S Armando Villalta; Paul J Wolters
Journal:  J Immunol       Date:  2008-10-15       Impact factor: 5.422

10.  Direct crosstalk between mast cell-TNF and TNFR1-expressing endothelia mediates local tissue inflammation.

Authors:  Manfred Kneilling; Reinhard Mailhammer; Lothar Hültner; Tanja Schönberger; Kerstin Fuchs; Martin Schaller; Daniel Bukala; Steffen Massberg; Christian A Sander; Heidi Braumüller; Martin Eichner; Konrad L Maier; Rupert Hallmann; Bernd J Pichler; Roland Haubner; Meinrad Gawaz; Klaus Pfeffer; Tilo Biedermann; Martin Röcken
Journal:  Blood       Date:  2009-06-22       Impact factor: 22.113
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