Literature DB >> 27877974

Inhibition of Alzheimer amyloid β aggregation by polyvalent trehalose.

Yoshiko Miura1, Chouga You2, Reiko Ohnishi3.   

Abstract

A glycopolymer carrying trehalose was found to suppress the formation of amyloid fibrils from the amyloid β peptide (1-42) (Aβ), as evaluated by thioflavin T assay and atomic force microscopy. Glycopolymers carrying sugar alcohols also changed the aggregation properties of Aβ, and the inhibitory effect depended on the type of sugar and alkyl side chain. Neutralization activity was confirmed by in vitro assay using HeLa cells. The glycopolymer carrying trehalose strongly inhibited amyloid formation and neutralized cytotoxicity.

Entities:  

Keywords:  amphiphilicity; amyloid; glycopolymer; multivalent effect

Year:  2008        PMID： 27877974      PMCID： PMC5099731          DOI： 10.1088/1468-6996/9/2/024407

Source DB:  PubMed          Journal:  Sci Technol Adv Mater        ISSN： 1468-6996            Impact factor:   8.090


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