Karina Quevedo1, Rowena Ng2, Hannah Scott3, Srivastava Kodavaganti4, Garry Smyda5, Vaibhav Diwadkar6, Mary Phillips7. 1. University of Minnesota, Department of Psychiatry, MN, USA. Electronic address: queve001@umn.edu. 2. University of Minnesota, Institute of Child Development, 51 East River Road, Minneapolis, MN, 55455, USA. Electronic address: rowenang@umn.edu. 3. University of Minnesota, Department of Psychiatry, MN, USA. Electronic address: hlscott@umn.edu. 4. University of Pittsburgh, School of Public Health, PA, USA. Electronic address: srk37@pitt.edu. 5. University of Pittsburgh, School of Public Health, PA, USA. Electronic address: gwsmyda@gmail.com. 6. Dept. of Psychiatry & Behavioral Neurosciences, Wayne State University School of Medicine, Suite 5B, Tolan Park Medical Building, 3901 Chrysler Service Drive, Detroit, MI, 48201, USA. Electronic address: vdiwadka@med.wayne.edu. 7. Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Electronic address: phillipsml@upmc.edu.
Abstract
BACKGROUND: The ventral striatum (VS) and striatal network supports goal motivated behavior. Identifying how depressed patients differ in their striatal network during the processing of emotionally salient events is a step towards uncovering biomarkers for diagnosis and treatment. METHODS: 38 depressed and 30 healthy adults completed a task that examined brain activation to the anticipation and receipt of monetary rewards and losses. Data were collected using a 3T Siemens Trio scanner. Functional connectivity differences were examined with seeds in the Left or Right VS. FC estimates were regressed on specific symptoms. RESULTS: Depressed patients displayed higher functional connectivity between the VS and midline cortical areas during loss versus reward trials. Anhedonia and depressed mood were associated to fairly similar striatal circuits but suicidality was associated to a unique VS-midline structures coupling, while depression severity was linked to higher VS to caudate and precuneus connectivity during loss versus reward trials. CONCLUSIONS: Depression is characterized by excessive VS coupling to cognitive control and associative networks during losses versus rewards. High VS to midline cortical structures coupling may index suicidality.
BACKGROUND: The ventral striatum (VS) and striatal network supports goal motivated behavior. Identifying how depressedpatients differ in their striatal network during the processing of emotionally salient events is a step towards uncovering biomarkers for diagnosis and treatment. METHODS: 38 depressed and 30 healthy adults completed a task that examined brain activation to the anticipation and receipt of monetary rewards and losses. Data were collected using a 3T Siemens Trio scanner. Functional connectivity differences were examined with seeds in the Left or Right VS. FC estimates were regressed on specific symptoms. RESULTS:Depressedpatients displayed higher functional connectivity between the VS and midline cortical areas during loss versus reward trials. Anhedonia and depressed mood were associated to fairly similar striatal circuits but suicidality was associated to a unique VS-midline structures coupling, while depression severity was linked to higher VS to caudate and precuneus connectivity during loss versus reward trials. CONCLUSIONS:Depression is characterized by excessive VS coupling to cognitive control and associative networks during losses versus rewards. High VS to midline cortical structures coupling may index suicidality.
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