Literature DB >> 27874289

Epigenetic changes as prognostic predictors in endometrial carcinomas.

Sanja A Farkas1, Bengt G Sorbe2, Torbjörn K Nilsson3.   

Abstract

Endometrial carcinoma is one of the most frequent gynecological malignancies of the female. The diagnostic and prognostic markers for the high-risk subgroups with unfavorable prognosis are under intense debate worldwide, and, therefore, the aim of this study was to identify new potential DNA methylation markers for the high-risk groups. We used the Illumina Infinium HumanMethylation450 BeadChip to analyze the DNA methylation pattern and investigated its association with clinicopathological features important for defining the high-risk (FIGO-grade 3) and low-risk (FIGO-grade 1) groups of patients with endometrial cancer (n = 31 and n = 39, respectively). We identified specific DNA methylation signature in high-risk endometrial tumors, and potential molecular biomarker genes (TBX2, CHST11, and NID2) associated with unfavorable clinical predictive and prognostic factors.

Entities:  

Keywords:  DNA methylation; FIGO grade; endometrial cancer; prognosis

Mesh：

Substances：

Year:  2016        PMID： 27874289      PMCID： PMC5270631          DOI： 10.1080/15592294.2016.1252891

Source DB:  PubMed          Journal:  Epigenetics        ISSN： 1559-2294            Impact factor:   4.528


  29 in total

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