Literature DB >> 27871852

Some pungent arguments against the physico-chemical theories of the origin of the genetic code and corroborating the coevolution theory.

Massimo Di Giulio1.   

Abstract

Whereas it is extremely easy to prove that "if the biosynthetic relationships between amino acids were fundamental in the structuring of the genetic code, then their physico-chemical properties might also be revealed in the genetic code table"; it is, on the contrary, impossible to prove that "if the physico-chemical properties of amino acids were fundamental in the structuring of the genetic code, then the presence of the biosynthetic relationships between amino acids should not be revealed in the genetic code". And, given that in the genetic code table are mirrored both the biosynthetic relationships between amino acids and their physico-chemical properties, all this would be a test that would falsify the physico-chemical theories of the origin of the genetic code. That is to say, if the physico-chemical properties of amino acids had a fundamental role in organizing the genetic code, then we would not have duly revealed the presence - in the genetic code - of the biosynthetic relationships between amino acids, and on the contrary this has been observed. Therefore, this falsifies the physico-chemical theories of genetic code origin. Whereas, the coevolution theory of the origin of the genetic code would be corroborated by this analysis, because it would be able to give a description of evolution of the genetic code more coherent with the indisputable empirical observations that link both the biosynthetic relationships of amino acids and their physico-chemical properties to the evolutionary organization of the genetic code.
Copyright © 2016 Elsevier Ltd. All rights reserved.

Keywords:  Coevolution theory of genetic code origin; Genetic code theory falsification test; Physico-chemical theories of genetic code origin

Mesh:

Year:  2016        PMID: 27871852     DOI: 10.1016/j.jtbi.2016.11.014

Source DB:  PubMed          Journal:  J Theor Biol        ISSN: 0022-5193            Impact factor:   2.691


  8 in total

1.  A Non-neutral Origin for Error Minimization in the Origin of the Genetic Code.

Authors:  Massimo Di Giulio
Journal:  J Mol Evol       Date:  2018-10-25       Impact factor: 2.395

2.  Genetic Code Optimization for Cotranslational Protein Folding: Codon Directional Asymmetry Correlates with Antiparallel Betasheets, tRNA Synthetase Classes.

Authors:  Hervé Seligmann; Ganesh Warthi
Journal:  Comput Struct Biotechnol J       Date:  2017-08-12       Impact factor: 7.271

3.  Optimization of the standard genetic code according to three codon positions using an evolutionary algorithm.

Authors:  Paweł Błażej; Małgorzata Wnętrzak; Dorota Mackiewicz; Paweł Mackiewicz
Journal:  PLoS One       Date:  2018-08-09       Impact factor: 3.240

4.  The influence of different types of translational inaccuracies on the genetic code structure.

Authors:  Paweł BłaŻej; Małgorzata Wnetrzak; Dorota Mackiewicz; Paweł Mackiewicz
Journal:  BMC Bioinformatics       Date:  2019-03-06       Impact factor: 3.169

Review 5.  A tRNA- and Anticodon-Centric View of the Evolution of Aminoacyl-tRNA Synthetases, tRNAomes, and the Genetic Code.

Authors:  Yunsoo Kim; Kristopher Opron; Zachary F Burton
Journal:  Life (Basel)       Date:  2019-05-04

6.  Optimization of amino acid replacement costs by mutational pressure in bacterial genomes.

Authors:  Paweł Błażej; Dorota Mackiewicz; Małgorzata Grabińska; Małgorzata Wnętrzak; Paweł Mackiewicz
Journal:  Sci Rep       Date:  2017-04-21       Impact factor: 4.379

7.  Intrinsic Properties of tRNA Molecules as Deciphered via Bayesian Network and Distribution Divergence Analysis.

Authors:  Sergio Branciamore; Grigoriy Gogoshin; Massimo Di Giulio; Andrei S Rodin
Journal:  Life (Basel)       Date:  2018-02-08

8.  On the Origin of Frameshift-Robustness of the Standard Genetic Code.

Authors:  Haiqing Xu; Jianzhi Zhang
Journal:  Mol Biol Evol       Date:  2021-09-27       Impact factor: 16.240

  8 in total

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