Pan Gao1, Hong-Hui Rong2, Ting Lu1, Gang Tang1, Liang-Yi Si1, James A Lederer3, Wei Xiong4. 1. Department of Geriatrics, The First Affiliated Hospital to Third Military Medical University, Southwest Hospital, Chongqing, China. 2. Department of Health Education, College of Preventive Medicine, Third Military Medical University, Chongqing, China. 3. Department of Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, US. Electronic address: jlederer@rics.bwh.harvard.edu. 4. Department of Geriatrics, The First Affiliated Hospital to Third Military Medical University, Southwest Hospital, Chongqing, China. Electronic address: 934812558@qq.com.
Abstract
OBJECTIVE: The aim of this study was to investigate the relationship between number of circulating T cells and coronary artery disease (CAD) in an elderly Chinese population. METHODS: A total of 295 elderly inpatients (age≥60) were included in this cross-sectional study. Their clinical and biochemical characteristics were recorded. Patients were divided to two groups: control patients and CAD patients. The risk factors of CAD were explored by binary logistic regression analysis. RESULTS: Compared with control patients, the ratio of CD4 to CD8 T cells was significantly increased in CAD patients. There was no difference in the number of CD3, CD4, and CD8 T cells between the two groups. Multiple logistic regression analysis showed that CAD was independently associated with age, gender, body mass index (BMI), systolic blood pressure (SBP), chronic heart failure (CHF) and the CD4/CD8 ratio. In addition, after adjusting for different clinical parameters (including gender, age, CHF, hypertension, arrhythmia, SBP, and BMI), the risk of CAD was significantly increased in patients with a CD4/CD8 ratio>1.5. CONCLUSIONS: There was a strong and independent association between the ratio of CD4/CD8 and CAD in elderly Chinese population.
OBJECTIVE: The aim of this study was to investigate the relationship between number of circulating T cells and coronary artery disease (CAD) in an elderly Chinese population. METHODS: A total of 295 elderly inpatients (age≥60) were included in this cross-sectional study. Their clinical and biochemical characteristics were recorded. Patients were divided to two groups: control patients and CAD patients. The risk factors of CAD were explored by binary logistic regression analysis. RESULTS: Compared with control patients, the ratio of CD4 to CD8 T cells was significantly increased in CAD patients. There was no difference in the number of CD3, CD4, and CD8 T cells between the two groups. Multiple logistic regression analysis showed that CAD was independently associated with age, gender, body mass index (BMI), systolic blood pressure (SBP), chronic heart failure (CHF) and the CD4/CD8 ratio. In addition, after adjusting for different clinical parameters (including gender, age, CHF, hypertension, arrhythmia, SBP, and BMI), the risk of CAD was significantly increased in patients with a CD4/CD8 ratio>1.5. CONCLUSIONS: There was a strong and independent association between the ratio of CD4/CD8 and CAD in elderly Chinese population.
Authors: Moises A Huaman; Joseph E Qualls; Shinsmon Jose; Stephanie M Schmidt; Anissa Moussa; David G Kuhel; Eddy Konaniah; Ravi K Komaravolu; Carl J Fichtenbaum; George S Deepe; David Y Hui Journal: Front Immunol Date: 2020-12-18 Impact factor: 7.561