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Literature DB >> 27862936

Branched Gold Nanoparticle Coating of Clostridium novyi-NT Spores for CT-Guided Intratumoral Injection.

Wooram Park¹, Soojeong Cho¹, Xiaoke Huang¹, Andrew C Larson^1,2,3,4,5, Dong-Hyun Kim^1,2.

Abstract

Branched gold nanoparticle (BGNP)-coated Clostridium novyi-NT (C. novyi-NT) spores are developed for computed tomography (CT)-guided bacteriolytic tumor therapy. The BGNP-coated spores are successfully injected into a tumor site under CT image guidance. As a result, a strong antitumor effect is observed in a PC3 prostate tumor-bearing mouse model.

Entities: Chemical Disease Gene Species

Keywords: Clostridium novyi-NT; bacteriolytic tumor therapy; computed tomography image-guided therapy; gold nanoparticles

Mesh：

Substances：
Colloids
Gold

Year: 2016 PMID： 27862936 PMCID： PMC5288294 DOI： 10.1002/smll.201602722

Source DB: PubMed Journal: Small ISSN： 1613-6810 Impact factor: 13.281

32 in total

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2. Nanomedicine for Cancer Immunotherapy: Tracking Cancer-Specific T-Cells in Vivo with Gold Nanoparticles and CT Imaging.

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3. Graphene as cellular interface: electromechanical coupling with cells.

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Review 5. Mechanisms of cancer drug resistance.

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6. Pharmacologic and toxicologic evaluation of C. novyi-NT spores.

Authors: Luis A Diaz; Ian Cheong; Catherine A Foss; Xiaosong Zhang; Brock A Peters; Nishant Agrawal; Chetan Bettegowda; Baktiar Karim; Guosheng Liu; Khalid Khan; Xin Huang; Manu Kohli; Long H Dang; Paul Hwang; Ahava Vogelstein; Elizabeth Garrett-Mayer; Barry Kobrin; Martin Pomper; Shibin Zhou; Kenneth W Kinzler; Bert Vogelstein; David L Huso
Journal: Toxicol Sci Date: 2005-09-14 Impact factor: 4.849

7. Overcoming the hypoxic barrier to radiation therapy with anaerobic bacteria.

Authors: Chetan Bettegowda; Long H Dang; Ross Abrams; David L Huso; Larry Dillehay; Ian Cheong; Nishant Agrawal; Scott Borzillary; J Michael McCaffery; E Latice Watson; Kuo-Shyan Lin; Fred Bunz; Kwamena Baidoo; Martin G Pomper; Kenneth W Kinzler; Bert Vogelstein; Shibin Zhou
Journal: Proc Natl Acad Sci U S A Date: 2003-12-01 Impact factor: 11.205

8. Bacteriolytic therapy can generate a potent immune response against experimental tumors.

Authors: Nishant Agrawal; Chetan Bettegowda; Ian Cheong; Jean-Francois Geschwind; Charles G Drake; Edward L Hipkiss; Mitsuaki Tatsumi; Long H Dang; Luis A Diaz; Martin Pomper; Mohammad Abusedera; Richard L Wahl; Kenneth W Kinzler; Shibin Zhou; David L Huso; Bert Vogelstein
Journal: Proc Natl Acad Sci U S A Date: 2004-10-07 Impact factor: 11.205

9. Spore coat architecture of Clostridium novyi NT spores.

Authors: Marco Plomp; J Michael McCaffery; Ian Cheong; Xin Huang; Chetan Bettegowda; Kenneth W Kinzler; Shibin Zhou; Bert Vogelstein; Alexander J Malkin
Journal: J Bacteriol Date: 2007-06-22 Impact factor: 3.490

10. In vitro cytotoxicity testing of polycations: influence of polymer structure on cell viability and hemolysis.

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Review 2. Bacteria as Nanoparticle Carriers for Immunotherapy in Oncology.

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Review 3. New opportunities for nanoparticles in cancer immunotherapy.

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Review 4. Microbes as Medicines: Harnessing the Power of Bacteria in Advancing Cancer Treatment.

Authors: Shruti S Sawant; Suyash M Patil; Vivek Gupta; Nitesh K Kunda
Journal: Int J Mol Sci Date: 2020-10-14 Impact factor: 5.923

5. Therapeutic effect of local photothermal heating of gold nanoparticle-coated self-expandable metallic stents for suppressing granulation tissue formation in the mouse colon.

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