Literature DB >> 27857977

The Janus face of p21.

Konstantinos Evangelou1, Panagiotis Galanos1, Vassilis G Gorgoulis2.   

Abstract

Accumulating data support the bimodal action of several key cellular factors in cancer. The dogma of p21WAF1/Cip1 as a tumor suppressor has been recently challenged since new data support its tumor promoting features depending on the tumor environment. Here we discuss the Janus face of p21WAF1/Cip1.

Entities:  

Keywords:  Genomic instability; PCNA; p21WAF1/Cip1; p53; replication stress; tumor heterogeneity

Year:  2016        PMID： 27857977      PMCID： PMC5068172          DOI： 10.1080/23723556.2016.1215776

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  Myc degradation: dancing with ubiquitin ligases.

Authors:  Bruno Amati
Journal:  Proc Natl Acad Sci U S A       Date:  2004-06-08       Impact factor: 11.205

2.  Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing.

Authors:  Panagiotis Galanos; Konstantinos Vougas; David Walter; Alexander Polyzos; Apolinar Maya-Mendoza; Emma J Haagensen; Antonis Kokkalis; Fani-Marlen Roumelioti; Sarantis Gagos; Maria Tzetis; Begoña Canovas; Ana Igea; Akshay K Ahuja; Ralph Zellweger; Sofia Havaki; Emanuel Kanavakis; Dimitris Kletsas; Igor B Roninson; Spiros D Garbis; Massimo Lopes; Angel Nebreda; Dimitris Thanos; J Julian Blow; Paul Townsend; Claus Storgaard Sørensen; Jiri Bartek; Vassilis G Gorgoulis
Journal:  Nat Cell Biol       Date:  2016-06-20       Impact factor: 28.824

3.  p53 in tumour pathology: can we trust immunohistochemistry?--Revisited!

Authors:  P A Hall; D P Lane
Journal:  J Pathol       Date:  1994-01       Impact factor: 7.996

Review 4.  Translocations involving c-myc and c-myc function.

Authors:  L M Boxer; C V Dang
Journal:  Oncogene       Date:  2001-09-10       Impact factor: 9.867

Review 5.  p21 in cancer: intricate networks and multiple activities.

Authors:  Tarek Abbas; Anindya Dutta
Journal:  Nat Rev Cancer       Date:  2009-06       Impact factor: 60.716

6.  Regulation of ploidy and senescence by the AMPK-related kinase NUAK1.

Authors:  Nicolas Humbert; Naveenan Navaratnam; Arnaud Augert; Marco Da Costa; Sébastien Martien; Jing Wang; Dolores Martinez; Corinne Abbadie; David Carling; Yvan de Launoit; Jesus Gil; David Bernard
Journal:  EMBO J       Date:  2009-11-19       Impact factor: 11.598

7.  Nuclear accumulation of cyclin D1 during S phase inhibits Cul4-dependent Cdt1 proteolysis and triggers p53-dependent DNA rereplication.

Authors:  Priya Aggarwal; Matthew D Lessie; Douglas I Lin; Laura Pontano; Andrew B Gladden; Beth Nuskey; Ami Goradia; Mariusz A Wasik; Andres J P Klein-Szanto; Anil K Rustgi; Craig H Bassing; J Alan Diehl
Journal:  Genes Dev       Date:  2007-11-15       Impact factor: 11.361

Review 8.  Proliferating cell nuclear antigen (PCNA): a dancer with many partners.

Authors:  Giovanni Maga; Ulrich Hubscher
Journal:  J Cell Sci       Date:  2003-08-01       Impact factor: 5.285

9.  D-type cyclin-binding regions of proliferating cell nuclear antigen.

Authors:  S Matsuoka; M Yamaguchi; A Matsukage
Journal:  J Biol Chem       Date:  1994-04-15       Impact factor: 5.157

Review 10.  Aberrant regulation of FBW7 in cancer.

Authors:  Lixia Wang; Xiantao Ye; Yueyong Liu; Wenyi Wei; Zhiwei Wang
Journal:  Oncotarget       Date:  2014-04-30
  10 in total
  4 in total

Review 1.  The Multifaceted p21 (Cip1/Waf1/CDKN1A) in Cell Differentiation, Migration and Cancer Therapy.

Authors:  Nina-Naomi Kreis; Frank Louwen; Juping Yuan
Journal:  Cancers (Basel)       Date:  2019-08-21       Impact factor: 6.639

2.  PKC signal amplification suppresses non-small cell lung cancer growth by promoting p21 expression and phosphorylation.

Authors:  Shuyan Liu; Yayun Zhang; Qianyi Yang; Yingqiu Zhang; Han Liu; Mu-Hua Huang; Ruoyu Wang; Faqiang Lu
Journal:  Heliyon       Date:  2022-09-17

Review 3.  Mechanisms of TP53 Pathway Inactivation in Embryonic and Somatic Cells-Relevance for Understanding (Germ Cell) Tumorigenesis.

Authors:  Dennis M Timmerman; Tessa L Remmers; Sanne Hillenius; Leendert H J Looijenga
Journal:  Int J Mol Sci       Date:  2021-05-20       Impact factor: 5.923

4.  PKC Dependent p14ARF Phosphorylation on Threonine 8 Drives Cell Proliferation.

Authors:  Rosa Fontana; Daniela Guidone; Felicia Sangermano; Viola Calabrò; Alessandra Pollice; Girolama La Mantia; Maria Vivo
Journal:  Sci Rep       Date:  2018-05-04       Impact factor: 4.379
  4 in total

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