| Literature DB >> 27853818 |
Thomas J X Li1, Christian M Reidys2.
Abstract
In this paper we study properties of topological RNA structures, i.e. RNA contact structures with cross-serial interactions that are filtered by their topological genus. RNA secondary structures within this framework are topological structures having genus zero. We derive a new bivariate generating function whose singular expansion allows us to analyze the distributions of arcs, stacks, hairpin- , interior- and multi-loops. We then extend this analysis to H-type pseudoknots, kissing hairpins as well as 3-knots and compute their respective expectation values. Finally we discuss our results and put them into context with data obtained by uniform sampling structures of fixed genus.Keywords: Fatgraph; Generating function; Genus; Loop; Pseudoknot; RNA structure; Singularity analysis
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Year: 2016 PMID: 27853818 DOI: 10.1007/s00285-016-1078-1
Source DB: PubMed Journal: J Math Biol ISSN: 0303-6812 Impact factor: 2.259