AIM: To evaluate the association between retinal capillary non-perfusion and diabetic retinopathy (DR) severity using optical coherence tomography-based microangiography (OMAG). METHODS: 33 patients (51 eyes) with a history of diabetes underwent imaging with a 68 kHz Cirrus-5000 spectral domain OMAG prototype. Demographic and clinical characteristics were collected. The perfusion index (PI) was defined as per cent coverage of area by retinal vessels with flow, measured within a minimum of 6.8×6.8 mm2 OMAG scan. The PI in each ETDRS zone was analysed using an automated algorithm. Univariate and multivariate analyses were used to determine the degree of association between PI and DR severity. RESULTS: 51 eyes with different DR severities were imaged. More severe DR was significantly associated with lower PI after adjusting for logarithm of the minimum angle of resolution best-corrected visual acuity, hyperlipidaemia, diabetes type and ETDRS ring in a multivariate mixed linear model. Compared with the none-mild non-proliferative diabetic retinopathy (NPDR) group, the moderate-severe NPDR group had 2.7 lower PI (p=0.03) and proliferative DR group had 4.3 lower PI (p=0.003). All ETDRS zones except for the foveal centre showed inverse associations between PI and DR severity (p values<0.001 to 0.862). CONCLUSIONS: A statistically significant inverse association exists between PI and DR severity. Our study suggests that PI may become a useful biomarker in evaluating and following the progression of DR. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.
AIM: To evaluate the association between retinal capillary non-perfusion and diabetic retinopathy (DR) severity using optical coherence tomography-based microangiography (OMAG). METHODS: 33 patients (51 eyes) with a history of diabetes underwent imaging with a 68 kHz Cirrus-5000 spectral domain OMAG prototype. Demographic and clinical characteristics were collected. The perfusion index (PI) was defined as per cent coverage of area by retinal vessels with flow, measured within a minimum of 6.8×6.8 mm2 OMAG scan. The PI in each ETDRS zone was analysed using an automated algorithm. Univariate and multivariate analyses were used to determine the degree of association between PI and DR severity. RESULTS: 51 eyes with different DR severities were imaged. More severe DR was significantly associated with lower PI after adjusting for logarithm of the minimum angle of resolution best-corrected visual acuity, hyperlipidaemia, diabetes type and ETDRS ring in a multivariate mixed linear model. Compared with the none-mild non-proliferative diabetic retinopathy (NPDR) group, the moderate-severe NPDR group had 2.7 lower PI (p=0.03) and proliferative DR group had 4.3 lower PI (p=0.003). All ETDRS zones except for the foveal centre showed inverse associations between PI and DR severity (p values<0.001 to 0.862). CONCLUSIONS: A statistically significant inverse association exists between PI and DR severity. Our study suggests that PI may become a useful biomarker in evaluating and following the progression of DR. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.
Authors: Kanishka R Mendis; Chandrakumar Balaratnasingam; Paula Yu; Chris J Barry; Ian L McAllister; Stephen J Cringle; Dao-Yi Yu Journal: Invest Ophthalmol Vis Sci Date: 2010-05-26 Impact factor: 4.799
Authors: Ruikang K Wang; Steven L Jacques; Zhenhe Ma; Sawan Hurst; Stephen R Hanson; Andras Gruber Journal: Opt Express Date: 2007-04-02 Impact factor: 3.894
Authors: Thomas Klein; Wolfgang Wieser; Christoph M Eigenwillig; Benjamin R Biedermann; Robert Huber Journal: Opt Express Date: 2011-02-14 Impact factor: 3.894
Authors: K A Kwiterovich; M G Maguire; R P Murphy; A P Schachat; N M Bressler; S B Bressler; S L Fine Journal: Ophthalmology Date: 1991-07 Impact factor: 12.079
Authors: Thomas S Hwang; Yali Jia; Simon S Gao; Steven T Bailey; Andreas K Lauer; Christina J Flaxel; David J Wilson; David Huang Journal: Retina Date: 2015-11 Impact factor: 4.256
Authors: Stephen A Burns; Ann E Elsner; Kaitlyn A Sapoznik; Raymond L Warner; Thomas J Gast Journal: Prog Retin Eye Res Date: 2018-08-27 Impact factor: 21.198
Authors: Qinqin Zhang; Yingying Shi; Hao Zhou; Giovanni Gregori; Zhongdi Chu; Fang Zheng; Elie H Motulsky; Luis de Sisternes; Mary Durbin; Philip J Rosenfeld; Ruikang K Wang Journal: Quant Imaging Med Surg Date: 2018-08
Authors: Cecilia S Lee; Ariel J Tyring; Yue Wu; Sa Xiao; Ariel S Rokem; Nicolaas P DeRuyter; Qinqin Zhang; Adnan Tufail; Ruikang K Wang; Aaron Y Lee Journal: Sci Rep Date: 2019-04-05 Impact factor: 4.379
Authors: Fang Yao Tang; Danny S Ng; Alexander Lam; Fiona Luk; Raymond Wong; Carmen Chan; Shaheeda Mohamed; Angie Fong; Jerry Lok; Tiffany Tso; Frank Lai; Marten Brelen; Tien Y Wong; Clement C Tham; Carol Y Cheung Journal: Sci Rep Date: 2017-05-31 Impact factor: 4.379
Authors: Mohamed Ashraf; Konstantina Sampani; Omar Abu-Qamar; Jerry Cavallerano; Paolo S Silva; Lloyd Paul Aiello; Jennifer K Sun Journal: Transl Vis Sci Technol Date: 2020-06-05 Impact factor: 3.283