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Literature DB >> 27847387

Bio-based production of fuels and industrial chemicals by repurposing antibiotic-producing type I modular polyketide synthases: opportunities and challenges.

Satoshi Yuzawa¹, Jay D Keasling^1,2,3,4,5,6, Leonard Katz².

Abstract

Complex polyketides comprise a large number of natural products that have broad application in medicine and agriculture. They are produced in bacteria and fungi from large enzyme complexes named type I modular polyketide synthases (PKSs) that are composed of multifunctional polypeptides containing discrete enzymatic domains organized into modules. The modular nature of PKSs has enabled a multitude of efforts to engineer the PKS genes to produce novel polyketides of predicted structure. We have repurposed PKSs to produce a number of short-chain mono- and di-carboxylic acids and ketones that could have applications as fuels or industrial chemicals.

Entities: Chemical

Mesh：

Substances：

Year: 2016 PMID： 27847387 DOI： 10.1038/ja.2016.136

Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649

36 in total

1. A polylinker approach to reductive loop swaps in modular polyketide synthases.

Authors: Laurenz Kellenberger; Ian S Galloway; Guido Sauter; Günter Böhm; Ulf Hanefeld; Jesús Cortés; James Staunton; Peter F Leadlay
Journal: Chembiochem Date: 2008-11-03 Impact factor: 3.164

2. Design, construction and characterisation of a synthetic promoter library for fine-tuned gene expression in actinomycetes.

Authors: Theresa Siegl; Bogdan Tokovenko; Maksym Myronovskyi; Andriy Luzhetskyy
Journal: Metab Eng Date: 2013-07-20 Impact factor: 9.783

3. Broad substrate specificity of the loading didomain of the lipomycin polyketide synthase.

Authors: Satoshi Yuzawa; Clara H Eng; Leonard Katz; Jay D Keasling
Journal: Biochemistry Date: 2013-05-23 Impact factor: 3.162

4. Enzyme analysis of the polyketide synthase leads to the discovery of a novel analog of the antibiotic α-lipomycin.

Authors: Satoshi Yuzawa; Clara H Eng; Leonard Katz; Jay D Keasling
Journal: J Antibiot (Tokyo) Date: 2013-10-30 Impact factor: 2.649

5. CRISPR-Cas9 Based Engineering of Actinomycetal Genomes.

Authors: Yaojun Tong; Pep Charusanti; Lixin Zhang; Tilmann Weber; Sang Yup Lee
Journal: ACS Synth Biol Date: 2015-04-07 Impact factor: 5.110

6. Engineering of bacterial methyl ketone synthesis for biofuels.

Authors: Ee-Been Goh; Edward E K Baidoo; Jay D Keasling; Harry R Beller
Journal: Appl Environ Microbiol Date: 2011-10-28 Impact factor: 4.792

Review 7. Beyond ethylmalonyl-CoA: the functional role of crotonyl-CoA carboxylase/reductase homologs in expanding polyketide diversity.

Authors: Micheal C Wilson; Bradley S Moore
Journal: Nat Prod Rep Date: 2011-11-29 Impact factor: 13.423

8. Uncovering the formation and selection of benzylmalonyl-CoA from the biosynthesis of splenocin and enterocin reveals a versatile way to introduce amino acids into polyketide carbon scaffolds.

Authors: Chenchen Chang; Rong Huang; Yan Yan; Hongmin Ma; Zheng Dai; Benying Zhang; Zixin Deng; Wen Liu; Xudong Qu
Journal: J Am Chem Soc Date: 2015-03-19 Impact factor: 15.419

9. Alteration of Polyketide Stereochemistry from anti to syn by a Ketoreductase Domain Exchange in a Type I Modular Polyketide Synthase Subunit.

Authors: Clara H Eng; Satoshi Yuzawa; George Wang; Edward E K Baidoo; Leonard Katz; Jay D Keasling
Journal: Biochemistry Date: 2016-03-15 Impact factor: 3.162

Bio-based production of fuels and industrial chemicals by repurposing antibiotic-producing type I modular polyketide synthases: opportunities and challenges.

1. A polylinker approach to reductive loop swaps in modular polyketide synthases.

2. Design, construction and characterisation of a synthetic promoter library for fine-tuned gene expression in actinomycetes.

3. Broad substrate specificity of the loading didomain of the lipomycin polyketide synthase.

4. Enzyme analysis of the polyketide synthase leads to the discovery of a novel analog of the antibiotic α-lipomycin.

5. CRISPR-Cas9 Based Engineering of Actinomycetal Genomes.

6. Engineering of bacterial methyl ketone synthesis for biofuels.

Review 7. Beyond ethylmalonyl-CoA: the functional role of crotonyl-CoA carboxylase/reductase homologs in expanding polyketide diversity.

8. Uncovering the formation and selection of benzylmalonyl-CoA from the biosynthesis of splenocin and enterocin reveals a versatile way to introduce amino acids into polyketide carbon scaffolds.

9. Alteration of Polyketide Stereochemistry from anti to syn by a Ketoreductase Domain Exchange in a Type I Modular Polyketide Synthase Subunit.

Review 10. Natural products as biofuels and bio-based chemicals: fatty acids and isoprenoids.

Review 1. Emerging evolutionary paradigms in antibiotic discovery.

Review 2. Engineering modular polyketide synthases for production of biofuels and industrial chemicals.

3. Development of a cyanobacterial heterologous polyketide production platform.

Review 4. Microbial pathways for advanced biofuel production.

5. ClusterCAD: a computational platform for type I modular polyketide synthase design.