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Literature DB >> 28946011

Engineering modular polyketide synthases for production of biofuels and industrial chemicals.

Abstract

Polyketide synthases (PKSs) are one of the most profound biosynthetic factories for producing polyketides with diverse structures and biological activities. These enzymes have been historically studied and engineered to make un-natural polyketides for drug discovery, and have also recently been explored for synthesizing biofuels and industrial chemicals due to their versatility and customizability. Here, we review recent advances in the mechanistic understanding and engineering of modular PKSs for producing polyketide-derived chemicals, and provide perspectives on this relatively new application of PKSs.

Entities: Chemical Disease Species

Mesh：

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Year: 2017 PMID： 28946011 PMCID： PMC5862724 DOI： 10.1016/j.copbio.2017.08.017

Source DB: PubMed Journal: Curr Opin Biotechnol ISSN： 0958-1669 Impact factor: 9.740

53 in total

1. Structure-based analysis of the molecular interactions between acyltransferase and acyl carrier protein in vicenistatin biosynthesis.

Authors: Akimasa Miyanaga; Shohei Iwasawa; Yuji Shinohara; Fumitaka Kudo; Tadashi Eguchi
Journal: Proc Natl Acad Sci U S A Date: 2016-02-01 Impact factor: 11.205

2. Microbial engineering for the production of advanced biofuels.

Authors: Pamela P Peralta-Yahya; Fuzhong Zhang; Stephen B del Cardayre; Jay D Keasling
Journal: Nature Date: 2012-08-16 Impact factor: 49.962

3. Mechanism and Stereochemistry of Polyketide Chain Elongation and Methyl Group Epimerization in Polyether Biosynthesis.

Authors: Xinqiang Xie; Ashish Garg; Chaitan Khosla; David E Cane
Journal: J Am Chem Soc Date: 2017-02-14 Impact factor: 15.419

4. Broadening substrate specificity of a chain-extending ketosynthase through a single active-site mutation.

Authors: Annabel C Murphy; Hui Hong; Steve Vance; R William Broadhurst; Peter F Leadlay
Journal: Chem Commun (Camb) Date: 2016-06-28 Impact factor: 6.222

5. Protein-Protein Interactions, Not Substrate Recognition, Dominate the Turnover of Chimeric Assembly Line Polyketide Synthases.

Authors: Maja Klaus; Matthew P Ostrowski; Jonas Austerjost; Thomas Robbins; Brian Lowry; David E Cane; Chaitan Khosla
Journal: J Biol Chem Date: 2016-05-31 Impact factor: 5.157

Review 6. Combinatorial biosynthesis of polyketides--a perspective.

Authors: Fong T Wong; Chaitan Khosla
Journal: Curr Opin Chem Biol Date: 2012-02-16 Impact factor: 8.822

7. Engineering an iterative polyketide pathway in Escherichia coli results in single-form alkene and alkane overproduction.

Authors: Qian Liu; Kaiyue Wu; Yongbo Cheng; Lei Lu; Erting Xiao; Yuchen Zhang; Zixin Deng; Tiangang Liu
Journal: Metab Eng Date: 2014-12-20 Impact factor: 9.783

8. Alteration of Polyketide Stereochemistry from anti to syn by a Ketoreductase Domain Exchange in a Type I Modular Polyketide Synthase Subunit.

Authors: Clara H Eng; Satoshi Yuzawa; George Wang; Edward E K Baidoo; Leonard Katz; Jay D Keasling
Journal: Biochemistry Date: 2016-03-15 Impact factor: 3.162

9. α-Methylation follows condensation in the gephyronic acid modular polyketide synthase.

Authors: Drew T Wagner; D Cole Stevens; M Rachel Mehaffey; Hannah R Manion; Richard E Taylor; Jennifer S Brodbelt; Adrian T Keatinge-Clay
Journal: Chem Commun (Camb) Date: 2016-07-07 Impact factor: 6.222

Review 10. Stereocontrol within polyketide assembly lines.

Authors: Adrian T Keatinge-Clay
Journal: Nat Prod Rep Date: 2016-02 Impact factor: 13.423

11 in total

1. Development of a Genetically Encoded Biosensor for Detection of Polyketide Synthase Extender Units in Escherichia coli.

Authors: Edward Kalkreuter; Aaron M Keeler; Alexandra A Malico; Kyle S Bingham; Anuran K Gayen; Gavin J Williams
Journal: ACS Synth Biol Date: 2019-05-28 Impact factor: 5.110

Engineering modular polyketide synthases for production of biofuels and industrial chemicals.

1. Structure-based analysis of the molecular interactions between acyltransferase and acyl carrier protein in vicenistatin biosynthesis.

2. Microbial engineering for the production of advanced biofuels.

3. Mechanism and Stereochemistry of Polyketide Chain Elongation and Methyl Group Epimerization in Polyether Biosynthesis.

4. Broadening substrate specificity of a chain-extending ketosynthase through a single active-site mutation.

5. Protein-Protein Interactions, Not Substrate Recognition, Dominate the Turnover of Chimeric Assembly Line Polyketide Synthases.

Review 6. Combinatorial biosynthesis of polyketides--a perspective.

7. Engineering an iterative polyketide pathway in Escherichia coli results in single-form alkene and alkane overproduction.

8. Alteration of Polyketide Stereochemistry from anti to syn by a Ketoreductase Domain Exchange in a Type I Modular Polyketide Synthase Subunit.

9. α-Methylation follows condensation in the gephyronic acid modular polyketide synthase.

Review 10. Stereocontrol within polyketide assembly lines.

1. Development of a Genetically Encoded Biosensor for Detection of Polyketide Synthase Extender Units in Escherichia coli.

Review 2. Emerging evolutionary paradigms in antibiotic discovery.

3. Heterologous Expression, Purification, and Characterization of Type II Polyketide Synthase Acyl Carrier Proteins.

4. Development of a cyanobacterial heterologous polyketide production platform.

Review 5. Microbial production of advanced biofuels.

Review 6. Microbial pathways for advanced biofuel production.

Review 7. Acyltransferases as Tools for Polyketide Synthase Engineering.

8. Modular type I polyketide synthase acyl carrier protein domains share a common N-terminally extended fold.

Review 9. Streptomyces as Microbial Chassis for Heterologous Protein Expression.

10. Reverse β-oxidation pathways for efficient chemical production.