Literature DB >> 27846206

Drug discovery: Doubling down on BET inhibition.

Dafydd Owen1.   

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Year:  2016        PMID： 27846206     DOI： 10.1038/nchembio.2242

Source DB:  PubMed          Journal:  Nat Chem Biol        ISSN： 1552-4450            Impact factor:   15.040


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  9 in total

1.  Disrupting Acetyl-Lysine Recognition: Progress in the Development of Bromodomain Inhibitors.

Authors:  F Anthony Romero; Alexander M Taylor; Terry D Crawford; Vickie Tsui; Alexandre Côté; Steven Magnuson
Journal:  J Med Chem       Date:  2015-12-01       Impact factor: 7.446

2.  Target validation using chemical probes.

Authors:  Mark E Bunnage; Eugene L Piatnitski Chekler; Lyn H Jones
Journal:  Nat Chem Biol       Date:  2013-04       Impact factor: 15.040

3.  Potent and selective bivalent inhibitors of BET bromodomains.

Authors:  Michael J Waring; Huawei Chen; Alfred A Rabow; Graeme Walker; Romel Bobby; Scott Boiko; Rob H Bradbury; Rowena Callis; Edwin Clark; Ian Dale; Danette L Daniels; Austin Dulak; Liz Flavell; Geoff Holdgate; Thomas A Jowitt; Alexey Kikhney; Mark McAlister; Jacqui Méndez; Derek Ogg; Joe Patel; Philip Petteruti; Graeme R Robb; Matthew B Robers; Sakina Saif; Natalie Stratton; Dmitri I Svergun; Wenxian Wang; David Whittaker; David M Wilson; Yi Yao
Journal:  Nat Chem Biol       Date:  2016-10-24       Impact factor: 15.040

4.  Suppression of inflammation by a synthetic histone mimic.

Authors:  Edwige Nicodeme; Kate L Jeffrey; Uwe Schaefer; Soren Beinke; Scott Dewell; Chun-Wa Chung; Rohit Chandwani; Ivan Marazzi; Paul Wilson; Hervé Coste; Julia White; Jorge Kirilovsky; Charles M Rice; Jose M Lora; Rab K Prinjha; Kevin Lee; Alexander Tarakhovsky
Journal:  Nature       Date:  2010-11-10       Impact factor: 49.962

5.  The Bromodomain: A New Target in Emerging Epigenetic Medicine.

Authors:  Steven G Smith; Ming-Ming Zhou
Journal:  ACS Chem Biol       Date:  2015-12-03       Impact factor: 5.100

6.  Discovery of AZD3514, a small-molecule androgen receptor downregulator for treatment of advanced prostate cancer.

Authors:  Robert H Bradbury; David G Acton; Nicola L Broadbent; A Nigel Brooks; Gregory R Carr; Glenn Hatter; Barry R Hayter; Kathryn J Hill; Nicholas J Howe; Rhys D O Jones; David Jude; Scott G Lamont; Sarah A Loddick; Heather L McFarland; Zaieda Parveen; Alfred A Rabow; Gorkhn Sharma-Singh; Natalie C Stratton; Andrew G Thomason; Dawn Trueman; Graeme E Walker; Stuart L Wells; Joanne Wilson; J Matthew Wood
Journal:  Bioorg Med Chem Lett       Date:  2013-02-21       Impact factor: 2.823

7.  Histone recognition and large-scale structural analysis of the human bromodomain family.

Authors:  Panagis Filippakopoulos; Sarah Picaud; Maria Mangos; Tracy Keates; Jean-Philippe Lambert; Dalia Barsyte-Lovejoy; Ildiko Felletar; Rudolf Volkmer; Susanne Müller; Tony Pawson; Anne-Claude Gingras; Cheryl H Arrowsmith; Stefan Knapp
Journal:  Cell       Date:  2012-03-30       Impact factor: 41.582

8.  Design and characterization of bivalent BET inhibitors.

Authors:  Minoru Tanaka; Justin M Roberts; Hyuk-Soo Seo; Amanda Souza; Joshiawa Paulk; Thomas G Scott; Stephen L DeAngelo; Sirano Dhe-Paganon; James E Bradner
Journal:  Nat Chem Biol       Date:  2016-10-24       Impact factor: 15.040

9.  Selective inhibition of BET bromodomains.

Authors:  Panagis Filippakopoulos; Jun Qi; Sarah Picaud; Yao Shen; William B Smith; Oleg Fedorov; Elizabeth M Morse; Tracey Keates; Tyler T Hickman; Ildiko Felletar; Martin Philpott; Shonagh Munro; Michael R McKeown; Yuchuan Wang; Amanda L Christie; Nathan West; Michael J Cameron; Brian Schwartz; Tom D Heightman; Nicholas La Thangue; Christopher A French; Olaf Wiest; Andrew L Kung; Stefan Knapp; James E Bradner
Journal:  Nature       Date:  2010-09-24       Impact factor: 49.962
  9 in total

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