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Literature DB >> 11095802

Reservoirs for HIV-1.

Abstract

The success of antiretroviral therapy for HIV-1 infection has generated interest in mechanisms by which the virus can persist in the body despite the presence of drugs that effectively inhibit key steps in the virus life cycle. There are several potential cellular and anatomic reservoirs for HIV-1. Among the most worrisome is a reservoir consisting of latently infected resting CD4+ T cells. Recent studies suggest that these cells can potentially provide a mechanism for life-long persistence of replication-competent forms of HIV-1, rendering unrealistic hopes of virus eradication with current antiretroviral regimens.

Entities: Disease Species

Year: 1999 PMID： 11095802 DOI： 10.1007/s11908-999-0033-3

Source DB: PubMed Journal: Curr Infect Dis Rep ISSN： 1523-3847 Impact factor: 3.725

61 in total

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Authors: G Pialoux; F Raffi; F Brun-Vezinet; V Meiffrédy; P Flandre; J A Gastaut; P Dellamonica; P Yeni; J F Delfraissy; J P Aboulker
Journal: N Engl J Med Date: 1998-10-29 Impact factor: 91.245

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Authors: T W Chun; D Engel; M M Berrey; T Shea; L Corey; A S Fauci
Journal: Proc Natl Acad Sci U S A Date: 1998-07-21 Impact factor: 11.205

1 in total

1. R5 and X4 HIV envelopes induce distinct gene expression profiles in primary peripheral blood mononuclear cells.

Authors: Claudia Cicala; James Arthos; Elena Martinelli; Nina Censoplano; Catherine C Cruz; Eva Chung; Sara M Selig; Donald Van Ryk; Jun Yang; Shyla Jagannatha; Tae Wook Chun; Ping Ren; Richard A Lempicki; Anthony S Fauci
Journal: Proc Natl Acad Sci U S A Date: 2006-02-27 Impact factor: 11.205

1 in total