Adam J DiPippo1, Frank P Tverdek2, Jeffrey J Tarrand3, Jose M Munita4, Truc T Tran5, Cesar A Arias6, Samuel A Shelburne7, Samuel L Aitken8. 1. Division of Pharmacy, Unit 0090, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA. Electronic address: ajdipippo@mdanderson.org. 2. Division of Pharmacy, Unit 0090, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA. Electronic address: fptverdek@mdanderson.org. 3. Department of Laboratory Medicine, Unit 0084, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA. Electronic address: jtarrand@mdanderson.org. 4. Center for Antimicrobial Resistance and Microbial Genomics, University of Texas McGovern School of Medicine, 6431 Fannin St, Houston, TX 77225, USA; Clinica Alemana, Universidad del Desarrollo, Av Vitacura 5951, Santiago, Región Metropolitana, Chile. Electronic address: jose.m.munita@uth.tmc.edu. 5. Center for Antimicrobial Resistance and Microbial Genomics, University of Texas McGovern School of Medicine, 6431 Fannin St, Houston, TX 77225, USA. Electronic address: truc.t.tran@uth.tmc.edu. 6. Center for Antimicrobial Resistance and Microbial Genomics, University of Texas McGovern School of Medicine, 6431 Fannin St, Houston, TX 77225, USA; Department of Infectious Diseases, Infection Control, and Employee Health, Unit 1460, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA. Electronic address: cesar.arias@uth.tmc.edu. 7. Department of Infectious Diseases, Infection Control, and Employee Health, Unit 1460, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA; Department of Genomic Medicine, Unit 1460, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA. Electronic address: sshelburne@mdanderson.org. 8. Division of Pharmacy, Unit 0090, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA; Center for Antimicrobial Resistance and Microbial Genomics, University of Texas McGovern School of Medicine, 6431 Fannin St, Houston, TX 77225, USA. Electronic address: slaitken@mdanderson.org.
Abstract
OBJECTIVES: We sought to determine the association between previous daptomycin exposure and daptomycin non-susceptible Enterococcus faecium (DNSEf) bloodstream infections (BSI) in adult leukemia patients. METHODS: We retrospectively identified adult (≥18 years old) leukemia patients with Enterococcus spp. bacteremia at The University of Texas MD Anderson Cancer Center (MDACC) from 6/1/2013 to 7/22/2015. Antimicrobial susceptibility and previous antibiotic exposure within the 90 days prior to bacteremia were collected. Classification and Regression Tree (CART) analysis was used to identify the most significant breakpoint between daptomycin exposure and DNSEf. RESULTS: Any amount of daptomycin received within the 90 days preceding BSI was significantly associated with isolation of DNSEf compared to daptomycin susceptible E. faecium (DSEf) (88% vs. 44%, respectively, p < 0.01). CART analysis identified receiving ≥13 days of daptomycin in the preceding 90 days as most significantly correlated with DNSEf (60% vs. 11%, relative risk [RR] 5.31, 95% Confidence interval [CI] 2.36-11.96, p < 0.01). CONCLUSIONS: Prior daptomycin exposure for ≥13 days within 90 days preceding BSI was significantly associated with isolation of DNSEf BSI in adult leukemia patients at our institution. Antimicrobial stewardship initiatives aimed at minimizing daptomycin exposure in high-risk patients may be of significant benefit in limiting the emergence of DNSEf.
OBJECTIVES: We sought to determine the association between previous daptomycin exposure and daptomycin non-susceptible Enterococcus faecium (DNSEf) bloodstream infections (BSI) in adult leukemiapatients. METHODS: We retrospectively identified adult (≥18 years old) leukemiapatients with Enterococcus spp. bacteremia at The University of Texas MD Anderson Cancer Center (MDACC) from 6/1/2013 to 7/22/2015. Antimicrobial susceptibility and previous antibiotic exposure within the 90 days prior to bacteremia were collected. Classification and Regression Tree (CART) analysis was used to identify the most significant breakpoint between daptomycin exposure and DNSEf. RESULTS: Any amount of daptomycin received within the 90 days preceding BSI was significantly associated with isolation of DNSEf compared to daptomycin susceptible E. faecium (DSEf) (88% vs. 44%, respectively, p < 0.01). CART analysis identified receiving ≥13 days of daptomycin in the preceding 90 days as most significantly correlated with DNSEf (60% vs. 11%, relative risk [RR] 5.31, 95% Confidence interval [CI] 2.36-11.96, p < 0.01). CONCLUSIONS: Prior daptomycin exposure for ≥13 days within 90 days preceding BSI was significantly associated with isolation of DNSEf BSI in adult leukemiapatients at our institution. Antimicrobial stewardship initiatives aimed at minimizing daptomycin exposure in high-risk patients may be of significant benefit in limiting the emergence of DNSEf.
Authors: Nathaniel J Rhodes; J Nicholas O'Donnell; Bryan D Lizza; Milena M McLaughlin; John S Esterly; Marc H Scheetz Journal: Antimicrob Agents Chemother Date: 2015-11-23 Impact factor: 5.191
Authors: James S Lewis; Aaron Owens; Jose Cadena; Kathryn Sabol; Jan E Patterson; James H Jorgensen Journal: Antimicrob Agents Chemother Date: 2005-04 Impact factor: 5.191
Authors: Paul A Harris; Robert Taylor; Robert Thielke; Jonathon Payne; Nathaniel Gonzalez; Jose G Conde Journal: J Biomed Inform Date: 2008-09-30 Impact factor: 6.317
Authors: Mini Kamboj; Nina Cohen; Kathleen Gilhuley; N Esther Babady; Susan K Seo; Kent A Sepkowitz Journal: Infect Control Hosp Epidemiol Date: 2011-04 Impact factor: 3.254
Authors: Cesar A Arias; Diana Panesso; Danielle M McGrath; Xiang Qin; Maria F Mojica; Corwin Miller; Lorena Diaz; Truc T Tran; Sandra Rincon; E Magda Barbu; Jinnethe Reyes; Jung H Roh; Elizabeth Lobos; Erica Sodergren; Renata Pasqualini; Wadih Arap; John P Quinn; Yousif Shamoo; Barbara E Murray; George M Weinstock Journal: N Engl J Med Date: 2011-09-08 Impact factor: 91.245
Authors: Evan J Zasowski; Kimberly C Claeys; Abdalhamid M Lagnf; Susan L Davis; Michael J Rybak Journal: Clin Infect Dis Date: 2016-03-03 Impact factor: 9.079
Authors: Bhavarth S Shukla; Samuel Shelburne; Katherine Reyes; Mini Kamboj; Jessica D Lewis; Sandra L Rincon; Jinnethe Reyes; Lina P Carvajal; Diana Panesso; Costi D Sifri; Marcus J Zervos; Eric G Pamer; Truc T Tran; Javier Adachi; Jose M Munita; Rodrigo Hasbun; Cesar A Arias Journal: Clin Infect Dis Date: 2016-04-03 Impact factor: 9.079
Authors: Jeremy C Storm; Daniel J Diekema; Jennifer S Kroeger; Sarah J Johnson; Birgir Johannsson Journal: Antimicrob Resist Infect Control Date: 2012-05-29 Impact factor: 4.887
Authors: Samira Dahesh; Brian Wong; Victor Nizet; George Sakoulas; Truc T Tran; Samuel L Aitken Journal: Antimicrob Agents Chemother Date: 2019-06-24 Impact factor: 5.191
Authors: Ayesha Khan; William R Miller; Dierdre Axell-House; Jose M Munita; Cesar A Arias Journal: J Clin Microbiol Date: 2022-06-13 Impact factor: 11.677
Authors: Farnaz Foolad; Brandie D Taylor; Samuel A Shelburne; Cesar A Arias; Samuel L Aitken Journal: J Antimicrob Chemother Date: 2018-09-01 Impact factor: 5.790
Authors: Lindsay M Avery; Joseph L Kuti; Maja Weisser; Adrian Egli; Michael J Rybak; Evan J Zasowski; Cesar A Arias; German A Contreras; Pearlie P Chong; Samuel L Aitken; Adam J DiPippo; Jann-Tay Wang; Nicholas S Britt; David P Nicolau Journal: Clin Infect Dis Date: 2019-05-02 Impact factor: 9.079
Authors: Julia A Messina; Rohita Sinha; Kimberly Starr; Mehreen Arshad; Barbara D Alexander; Nelson J Chao; Anthony D Sung Journal: Open Forum Infect Dis Date: 2018-05-05 Impact factor: 3.835
Authors: Clare L Kinnear; Elsa Hansen; Valerie J Morley; Kevin C Tracy; Meghan Forstchen; Andrew F Read; Robert J Woods Journal: PLoS Biol Date: 2020-12-17 Impact factor: 8.029
Authors: Rachael A Lee; Jason Goldman; Ghady Haidar; Jessica Lewis; Sana Arif; Jonathan Hand; Ricardo M La Hoz; Stephanie Pouch; Eric Holaday; Heather Clauss; Keith S Kaye; Anoma Nellore Journal: Open Forum Infect Dis Date: 2022-01-22 Impact factor: 3.835