Literature DB >> 27844469

The expression of Smad signaling pathway in myocardium and potential therapeutic effects.

Yuping Duan1,2, Wei Zhu3, Min Liu2, Muhammad Ashraf2, Meifeng Xu4.   

Abstract

Myocardial infarction (MI) is a life-threatening disease. The expression of Smad proteins in the ischemic myocardium changes significantly following myocardial infarction, suggesting a close relationship between Smad proteins and heart remodeling. Moreover, it is known that the expression of Smads is regulated by transforming growth factor-β (TGF-β) and bone morphogenetic proteins (BMP). Based on these findings, regulating the expression of Smad proteins by targeting TGF-β and BMP in the ischemic myocardium may be considered to be a possible therapeutic strategy for the treatment of myocardial infarction.

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Year:  2016        PMID： 27844469      PMCID： PMC5637726          DOI： 10.14670/HH-11-845

Source DB:  PubMed          Journal:  Histol Histopathol        ISSN： 0213-3911            Impact factor:   2.303


  99 in total

Review 1.  TGF beta-related pathways. Roles in Caenorhabditis elegans development.

Authors:  G I Patterson; R W Padgett
Journal:  Trends Genet       Date:  2000-01       Impact factor: 11.639

Review 2.  Mechanisms of TGF-beta signaling from cell membrane to the nucleus.

Authors:  Yigong Shi; Joan Massagué
Journal:  Cell       Date:  2003-06-13       Impact factor: 41.582

3.  Chronic angiotensin-(1-7) administration improves vascular remodeling after angioplasty through the regulation of the TGF-beta/Smad signaling pathway in rabbits.

Authors:  Wutao Zeng; Weiyan Chen; Xiuyu Leng; Jian Gui He; Hong Ma
Journal:  Biochem Biophys Res Commun       Date:  2009-08-26       Impact factor: 3.575

4.  Angiotensin II activates the Smad pathway in vascular smooth muscle cells by a transforming growth factor-beta-independent mechanism.

Authors:  Juan Rodríguez-Vita; Elsa Sánchez-López; Vanesa Esteban; Mónica Rupérez; Jesús Egido; Marta Ruiz-Ortega
Journal:  Circulation       Date:  2005-05-09       Impact factor: 29.690

5.  Abrogation of transforming growth factor-beta signaling by SMAD7 inhibits collagen gel contraction of human dermal fibroblasts.

Authors:  Jürgen Kopp; Ellen Preis; Harun Said; Bernd Hafemann; Lucia Wickert; Axel M Gressner; Norbert Pallua; Steven Dooley
Journal:  J Biol Chem       Date:  2005-03-23       Impact factor: 5.157

6.  Fluvastatin decreases cardiac fibrosis possibly through regulation of TGF-beta(1)/Smad 7 expression in the spontaneously hypertensive rats.

Authors:  Yuansheng Zhai; Xiuren Gao; Qiaomei Wu; Longyun Peng; Jun Lin; Zhiyi Zuo
Journal:  Eur J Pharmacol       Date:  2008-03-15       Impact factor: 4.432

7.  Excess SMAD signaling contributes to heart and muscle dysfunction in muscular dystrophy.

Authors:  Jeffery A Goldstein; Sasha Bogdanovich; Anastasia Beiriger; Lisa M Wren; Ann E Rossi; Quan Q Gao; Brandon B Gardner; Judy U Earley; Jeffery D Molkentin; Elizabeth M McNally
Journal:  Hum Mol Genet       Date:  2014-07-28       Impact factor: 6.150

Review 8.  BMP-7 counteracting TGF-beta1 activities in organ fibrosis.

Authors:  Ralf Weiskirchen; Steffen K Meurer
Journal:  Front Biosci (Landmark Ed)       Date:  2013-06-01

9.  PKCβII inhibition attenuates myocardial infarction induced heart failure and is associated with a reduction of fibrosis and pro-inflammatory responses.

Authors:  Suresh Selvaraj Palaniyandi; Julio Cesar Batista Ferreira; Patricia Chakur Brum; Daria Mochly-Rosen
Journal:  J Cell Mol Med       Date:  2011-08       Impact factor: 5.310

10.  Suppression of TGF-β1/Smad signaling pathway by sesamin contributes to the attenuation of myocardial fibrosis in spontaneously hypertensive rats.

Authors:  Mengqiu Zhao; Shuguo Zheng; Jieren Yang; Yuanjie Wu; Younan Ren; Xiang Kong; Wei Li; Jiali Xuan
Journal:  PLoS One       Date:  2015-03-20       Impact factor: 3.240
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  1 in total

1.  RNAseq shows an all-pervasive day-night rhythm in the transcriptome of the pacemaker of the heart.

Authors:  Yanwen Wang; Cali Anderson; Halina Dobrzynski; George Hart; Alicia D'Souza; Mark R Boyett
Journal:  Sci Rep       Date:  2021-02-11       Impact factor: 4.379
  1 in total

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