Lydie Beauport1, Juliane Schneider2, Mohamed Faouzi3, Patric Hagmann4, Petra S Hüppi5, Jean-François Tolsa6, Anita C Truttmann6, Céline J Fischer Fumeaux7. 1. Clinic of Neonatology, Department Woman-Mother-Child, Lausanne University Hospital, Lausanne, Switzerland; Division of Neonatology, Department of Pediatrics, Centre Hospitalier Chrétien, Site St-Vincent, Rocourt, Belgium. 2. Clinic of Neonatology, Department Woman-Mother-Child, Lausanne University Hospital, Lausanne, Switzerland; Division of Neurology, The Hospital for Sick Children, University of Toronto, Toronto, Canada. 3. Biostatitics, Institute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland. 4. Department of Radiology, Lausanne University Hospital, Lausanne, Switzerland. 5. Division of Development and Growth, Department of Pediatrics, University Hospital of Geneva, Geneva, Switzerland. 6. Clinic of Neonatology, Department Woman-Mother-Child, Lausanne University Hospital, Lausanne, Switzerland. 7. Clinic of Neonatology, Department Woman-Mother-Child, Lausanne University Hospital, Lausanne, Switzerland. Electronic address: celine-julie.fischer@chuv.ch.
Abstract
OBJECTIVES: To investigate the association between early nutritional intake and brain development assessed by magnetic resonance imaging (MRI). STUDY DESIGN: A cohort of neonates born at ≤30 weeks gestational age underwent MRI at term equivalent age. Brain maturation and injury were assessed using the Kidokoro score. Two groups were defined by severity of the scores. The associations between macronutrients intake during the first 2 weeks of life, clinical factors, and imaging scores were analyzed using logistic regression. RESULTS: MRI scores from group 1 patients (n = 27) were normal to mildly abnormal (0-5). Group 2 (n = 15) had more abnormal scores (6-12). The median gestational ages (IQR) were 27.4 (1.9) weeks in group 1 and 27.0 (2.9) weeks in group 2, with birth weights of 900 (318) g (group 1) and 844 (293) g (group 2). In group 2, energy, lipid, and carbohydrate intake were significantly lower than in group 1. Group 2 also showed higher rates of sepsis and clinical risk scores than group 1. After adjustments in bivariate models, higher energy and lipid intake remained significantly associated with improved scores on MRI. This association was stronger for the gray matter component of the score. CONCLUSIONS: Higher energy and lipid intake during the first 2 weeks after birth was associated with a lower incidence of brain lesions and dysmaturation at term equivalent age in preterm neonates.
OBJECTIVES: To investigate the association between early nutritional intake and brain development assessed by magnetic resonance imaging (MRI). STUDY DESIGN: A cohort of neonates born at ≤30 weeks gestational age underwent MRI at term equivalent age. Brain maturation and injury were assessed using the Kidokoro score. Two groups were defined by severity of the scores. The associations between macronutrients intake during the first 2 weeks of life, clinical factors, and imaging scores were analyzed using logistic regression. RESULTS: MRI scores from group 1 patients (n = 27) were normal to mildly abnormal (0-5). Group 2 (n = 15) had more abnormal scores (6-12). The median gestational ages (IQR) were 27.4 (1.9) weeks in group 1 and 27.0 (2.9) weeks in group 2, with birth weights of 900 (318) g (group 1) and 844 (293) g (group 2). In group 2, energy, lipid, and carbohydrate intake were significantly lower than in group 1. Group 2 also showed higher rates of sepsis and clinical risk scores than group 1. After adjustments in bivariate models, higher energy and lipid intake remained significantly associated with improved scores on MRI. This association was stronger for the gray matter component of the score. CONCLUSIONS: Higher energy and lipid intake during the first 2 weeks after birth was associated with a lower incidence of brain lesions and dysmaturation at term equivalent age in preterm neonates.
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