| Literature DB >> 27837280 |
Félix Javier Jiménez-Jiménez1,2, Elena García-Martín3, Hortensia Alonso-Navarro4,5, Carmen Martínez6, Martín Zurdo7, Laura Turpín-Fenoll8, Jorge Millán-Pascual8, Teresa Adeva-Bartolomé9, Esther Cubo10, Francisco Navacerrada4, Ana Rojo-Sebastián5, Lluisa Rubio5, Sara Ortega-Cubero11,12,13, Pau Pastor11,12,13,14, Marisol Calleja4, José Francisco Plaza-Nieto4, Belén Pilo-de-la-Fuente4, Margarita Arroyo-Solera4, Esteban García-Albea5, José A G Agúndez3.
Abstract
A recent meta-analysis suggests an association between the rs11558538 single nucleotide polymorphism in the histamine-N-methyl-transferase (HNMT) gene and the risk for Parkinson's disease. Based on the possible relationship between PD and restless legs syndrome (RLS), we tried to establish whether rs11558538 SNP is associated with the risk for RLS. We studied the genotype and allelic variant frequencies of HNMT rs11558538 SNP 205 RLS patients and 410 healthy controls using a TaqMan assay. The frequencies of the HNMT rs11558538 genotypes allelic variants were similar between RLS patients and controls, and were not influenced by gender, family history of RLS, or RLS severity. RLS patients carrying the genotype rs11558538TT had an earlier age at onset, but this finding was based on three subjects only. These results suggest a lack of major association between HNMT rs11558538 SNP and the risk for RLS.Entities:
Keywords: Genetics; HNMT gene; Polymorphisms; Restless legs syndrome; Risk factors
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Year: 2016 PMID： 27837280 DOI： 10.1007/s00702-016-1645-z
Source DB: PubMed Journal: J Neural Transm (Vienna) ISSN： 0300-9564 Impact factor: 3.575