BACKGROUND: Histamine N-methyltransferase (HNMT) is the main metabolizing enzyme of histamine (a mediator of inflammation implicated in the pathogenesis of multiple sclerosis-MS) in the CNS. We have investigated the possible association between a single nucleotide polymorphism of the HNMT (chromosome 2q22.1), that causes the amino acid substitution Thr105Ile (decreasing enzyme activity) and the risk for MS. METHODS: We studied the frequency of the HNMT genotypes and allelic variants in 228 MS patients and 295 healthy controls using a PCR-RLFP method. RESULTS: The frequencies of the HNMT genotypes and allelic variants did not differ significantly between MS patients and controls, and were unrelated with the age of onset of MS, gender, and course of MS. CONCLUSION: The HNMT polymorphism is not related with the risk for MS.
BACKGROUND:Histamine N-methyltransferase (HNMT) is the main metabolizing enzyme of histamine (a mediator of inflammation implicated in the pathogenesis of multiple sclerosis-MS) in the CNS. We have investigated the possible association between a single nucleotide polymorphism of the HNMT (chromosome 2q22.1), that causes the amino acid substitution Thr105Ile (decreasing enzyme activity) and the risk for MS. METHODS: We studied the frequency of the HNMT genotypes and allelic variants in 228 MS patients and 295 healthy controls using a PCR-RLFP method. RESULTS: The frequencies of the HNMT genotypes and allelic variants did not differ significantly between MS patients and controls, and were unrelated with the age of onset of MS, gender, and course of MS. CONCLUSION: The HNMT polymorphism is not related with the risk for MS.
Authors: Félix Javier Jiménez-Jiménez; Elena García-Martín; Hortensia Alonso-Navarro; Carmen Martínez; Martín Zurdo; Laura Turpín-Fenoll; Jorge Millán-Pascual; Teresa Adeva-Bartolomé; Esther Cubo; Francisco Navacerrada; Ana Rojo-Sebastián; Lluisa Rubio; Sara Ortega-Cubero; Pau Pastor; Marisol Calleja; José Francisco Plaza-Nieto; Belén Pilo-de-la-Fuente; Margarita Arroyo-Solera; Esteban García-Albea; José A G Agúndez Journal: J Neural Transm (Vienna) Date: 2016-11-11 Impact factor: 3.575
Authors: José A G Agúndez; Elena García-Martín; Carmen Martínez; Julián Benito-León; Jorge Millán-Pascual; Patricia Calleja; María Díaz-Sánchez; Diana Pisa; Laura Turpín-Fenoll; Hortensia Alonso-Navarro; Lucía Ayuso-Peralta; Dolores Torrecillas; José Francisco Plaza-Nieto; Félix Javier Jiménez-Jiménez Journal: BMC Neurol Date: 2014-04-23 Impact factor: 2.474
Authors: José A G Agúndez; Elena García-Martín; Carmen Martínez; Julián Benito-León; Jorge Millán-Pascual; María Díaz-Sánchez; Patricia Calleja; Diana Pisa; Laura Turpín-Fenoll; Hortensia Alonso-Navarro; Pau Pastor; Sara Ortega-Cubero; Lucía Ayuso-Peralta; Dolores Torrecillas; Esteban García-Albea; José Francisco Plaza-Nieto; Félix Javier Jiménez-Jiménez Journal: Sci Rep Date: 2016-02-12 Impact factor: 4.379
Authors: Elena García-Martín; Oswaldo Lorenzo-Betancor; Carmen Martínez; Pau Pastor; Julián Benito-León; Jorge Millán-Pascual; Patricia Calleja; María Díaz-Sánchez; Diana Pisa; Laura Turpín-Fenoll; Hortensia Alonso-Navarro; Lucía Ayuso-Peralta; Dolores Torrecillas; Elena Lorenzo; José Francisco Plaza-Nieto; José A G Agúndez; Félix Javier Jiménez-Jiménez Journal: BMC Neurol Date: 2013-04-10 Impact factor: 2.474