| Literature DB >> 27836240 |
Danielle de Souza Costa1, Antoine Bechara2, Jonas Jardim de Paula3, Marco Aurélio Romano-Silva4, Humberto Correa4, Guilherme Menezes Lage5, Débora Marques de Miranda6, Leandro Fernandes Malloy-Diniz4.
Abstract
The biological underpinnings of sex-related differences in decision-making are still under-explored. The COMT gene is related to sexual dimorphism and with different choices made under uncertainty, albeit no study has specifically investigated a moderation effect of sex on the association between the COMT gene and the performance on decision-making paradigms. In this study, we investigated the influence of the COMT Val158Met polymorphism on Iowa Gambling Task (IGT) performance depending on sex in a healthy adult sample. Participants were 192 healthy adults (84 men and 108 women). The first 40 choices in the IGT were considered decisions under ambiguity and the last 60 choices decisions under risk. To test our moderation hypothesis we used a separate regressions approach. The results revealed a sex-dependent effect of COMT Va l158Met polymorphism on decision-making as measured by the IGT. Val/Val women showed the best performance in the last trials of the IGT. Therefore, the COMT Val158Met polymorphism may be considered a genetic marker underlying sex differences in decision-making.Entities:
Keywords: Behavioral genetics; COMT Val(158)Met polymorphism; Decision-making; Dopamine; Molecular genetics; Neuropsychiatry; Neuropsychology; Sex
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Year: 2016 PMID： 27836240 DOI： 10.1016/j.psychres.2016.10.073
Source DB: PubMed Journal: Psychiatry Res ISSN： 0165-1781 Impact factor: 3.222