Literature DB >> 2783462

Inhibition of growth of human lung adenocarcinoma cell lines by anti-transforming growth factor-alpha monoclonal antibody.

K Imanishi1, K Yamaguchi, M Kuranami, E Kyo, T Hozumi, K Abe.   

Abstract

We previously reported that two human lung adenocarcinoma cell lines (A-549 and PC-9) produce human transforming growth factor-alpha (hTGF-alpha) and express its receptors. In the present study an exogenously added monoclonal antibody against recombinant hTGF-alpha inhibited growth of these cell lines in vitro. This result indicated that endogenous hTGF-alpha produced by the cancer cells can function as an autocrine growth factor.

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Year:  1989        PMID： 2783462     DOI： 10.1093/jnci/81.3.220

Source DB:  PubMed          Journal:  J Natl Cancer Inst        ISSN： 0027-8874            Impact factor:   13.506


  15 in total

1.  Interrupting autocrine ligand-receptor binding: comparison between receptor blockers and ligand decoys.

Authors:  K E Forsten; D A Lauffenburger
Journal:  Biophys J       Date:  1992-09       Impact factor: 4.033

2.  Autocrine ligand binding to cell receptors. Mathematical analysis of competition by solution "decoys".

Authors:  K E Forsten; D A Lauffenburger
Journal:  Biophys J       Date:  1992-02       Impact factor: 4.033

3.  Regulation of transforming growth factor alpha expression in a growth factor-independent cell line.

Authors:  G M Howell; L E Humphrey; B L Ziober; R Awwad; B Periyasamy; A Koterba; W Li; J K Willson; K Coleman; J Carboni; M Lynch; M G Brattain
Journal:  Mol Cell Biol       Date:  1998-01       Impact factor: 4.272

4.  Serum response heterogeneity among nonsmall cell lung cancer cell lines.

Authors:  K T Goldsmith; C M Listinsky; R I Garver
Journal:  Am J Pathol       Date:  1991-10       Impact factor: 4.307

5.  Frequent expression of genes for receptor tyrosine kinases and their ligands in human pancreatic cancer cells.

Authors:  T Oikawa; J Hitomi; A Kono; E Kaneko; K Yamaguchi
Journal:  Int J Pancreatol       Date:  1995-08

6.  MiR-374a suppresses lung adenocarcinoma cell proliferation and invasion by targeting TGFA gene expression.

Authors:  Haijian Wu; Yan Liu; Xiao Ou Shu; Qiuyin Cai
Journal:  Carcinogenesis       Date:  2016-03-31       Impact factor: 4.944

7.  In vitro and in vivo expressions of transforming growth factor-alpha and tyrosine kinase receptors in human non-small-cell lung carcinomas.

Authors:  C Liu; M S Tsao
Journal:  Am J Pathol       Date:  1993-04       Impact factor: 4.307

8.  Immunoreactive transforming growth factor alpha is commonly present in colorectal neoplasia.

Authors:  S Tanaka; K Imanishi; M Yoshihara; K Haruma; K Sumii; G Kajiyama; S Akamatsu
Journal:  Am J Pathol       Date:  1991-07       Impact factor: 4.307

9.  Proto-oncogene and growth factor/receptor expression in the establishment of primary human non-small cell lung carcinoma cell lines.

Authors:  C Liu; M S Tsao
Journal:  Am J Pathol       Date:  1993-02       Impact factor: 4.307

10.  A vasoactive intestinal peptide antagonist inhibits non-small cell lung cancer growth.

Authors:  T W Moody; F Zia; M Draoui; D E Brenneman; M Fridkin; A Davidson; I Gozes
Journal:  Proc Natl Acad Sci U S A       Date:  1993-05-15       Impact factor: 11.205
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