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Literature DB >> 27834347

A new target for differentiation therapy in AML.

Abstract

Despite major advances in understanding the genetics and epigenetics of acute myelogenous leukemia, there is still a great need to develop more specific and effective therapies. High throughput approaches involving either genetic approaches or small molecule inhibitor screens are beginning to identify promising new therapeutic targets.

Entities: Disease

Mesh：

Substances：

Year: 2016 PMID： 27834347 PMCID： PMC5223225 DOI： 10.1038/cr.2016.130

Source DB: PubMed Journal: Cell Res ISSN： 1001-0602 Impact factor: 25.617

6 in total

1. Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia.

Authors: David B Sykes; Youmna S Kfoury; François E Mercier; Mathias J Wawer; Jason M Law; Mark K Haynes; Timothy A Lewis; Amir Schajnovitz; Esha Jain; Dongjun Lee; Hanna Meyer; Kerry A Pierce; Nicola J Tolliday; Anna Waller; Steven J Ferrara; Ashley L Eheim; Detlef Stoeckigt; Katrina L Maxcy; Julien M Cobert; Jacqueline Bachand; Brian A Szekely; Siddhartha Mukherjee; Larry A Sklar; Joanne D Kotz; Clary B Clish; Ruslan I Sadreyev; Paul A Clemons; Andreas Janzer; Stuart L Schreiber; David T Scadden
Journal: Cell Date: 2016-09-15 Impact factor: 41.582

Review 2. O-GlcNAc and the epigenetic regulation of gene expression.

Authors: Brian A Lewis; John A Hanover
Journal: J Biol Chem Date: 2014-10-21 Impact factor: 5.157

Review 3. Role of HOXA9 in leukemia: dysregulation, cofactors and essential targets.

Authors: C T Collins; J L Hess
Journal: Oncogene Date: 2015-06-01 Impact factor: 9.867

Review 4. Emerging therapeutic drugs for AML.

Authors: Eytan M Stein; Martin S Tallman
Journal: Blood Date: 2015-12-10 Impact factor: 22.113

5. Retinoic acid and arsenic trioxide for acute promyelocytic leukemia.

Authors: Francesco Lo-Coco; Giuseppe Avvisati; Marco Vignetti; Christian Thiede; Sonia Maria Orlando; Simona Iacobelli; Felicetto Ferrara; Paola Fazi; Laura Cicconi; Eros Di Bona; Giorgina Specchia; Simona Sica; Mariadomenica Divona; Alessandro Levis; Walter Fiedler; Elisa Cerqui; Massimo Breccia; Giuseppe Fioritoni; Helmut R Salih; Mario Cazzola; Lorella Melillo; Angelo M Carella; Christian H Brandts; Enrica Morra; Marie von Lilienfeld-Toal; Bernd Hertenstein; Mohammed Wattad; Michael Lübbert; Matthias Hänel; Norbert Schmitz; Hartmut Link; Maria Grazia Kropp; Alessandro Rambaldi; Giorgio La Nasa; Mario Luppi; Fabio Ciceri; Olimpia Finizio; Adriano Venditti; Francesco Fabbiano; Konstanze Döhner; Michaela Sauer; Arnold Ganser; Sergio Amadori; Franco Mandelli; Hartmut Döhner; Gerhard Ehninger; Richard F Schlenk; Uwe Platzbecker
Journal: N Engl J Med Date: 2013-07-11 Impact factor: 91.245

6. A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia.

Authors: Konstantinos Tzelepis; Hiroko Koike-Yusa; Etienne De Braekeleer; Yilong Li; Emmanouil Metzakopian; Oliver M Dovey; Annalisa Mupo; Vera Grinkevich; Meng Li; Milena Mazan; Malgorzata Gozdecka; Shuhei Ohnishi; Jonathan Cooper; Miten Patel; Thomas McKerrell; Bin Chen; Ana Filipa Domingues; Paolo Gallipoli; Sarah Teichmann; Hannes Ponstingl; Ultan McDermott; Julio Saez-Rodriguez; Brian J P Huntly; Francesco Iorio; Cristina Pina; George S Vassiliou; Kosuke Yusa
Journal: Cell Rep Date: 2016-10-18 Impact factor: 9.423

6 in total

4 in total

1. The Transcriptional Network That Controls Growth Arrest and Macrophage Differentiation in the Human Myeloid Leukemia Cell Line THP-1.

Authors: Iveta Gažová; Lucas Lefevre; Stephen J Bush; Sara Clohisey; Erik Arner; Michiel de Hoon; Jessica Severin; Lucas van Duin; Robin Andersson; Andreas Lengeling; David A Hume; Kim M Summers
Journal: Front Cell Dev Biol Date: 2020-07-03