Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 O-GlcNAc and the epigenetic regulation of gene expression.

Literature DB >> 25336654

O-GlcNAc and the epigenetic regulation of gene expression.

Abstract

O-GlcNAcylation is an abundant nutrient-driven modification linked to cellular signaling and regulation of gene expression. Utilizing precursors derived from metabolic flux, O-GlcNAc functions as a homeostatic regulator. The enzymes of O-GlcNAc cycling, OGT and O-GlcNAcase, act in mitochondria, the cytoplasm, and the nucleus in association with epigenetic "writers" and "erasers" of the histone code. Both O-GlcNAc and O-phosphate modify repeats within the RNA polymerase II C-terminal domain (CTD). By communicating with the histone and CTD codes, O-GlcNAc cycling provides a link between cellular metabolic status and the epigenetic machinery. Thus, O-GlcNAcylation is poised to influence trans-generational epigenetic inheritance.

Entities: Chemical Gene

Keywords: Epigenetics; Glycobiology; Histones; O-GlcNAc; O-GlcNAcylation; Polycomb; RNA Polymerase II; Signaling; Transcription

Mesh：

Substances：

Year: 2014 PMID： 25336654 PMCID： PMC4263851 DOI： 10.1074/jbc.R114.595439

Source DB: PubMed Journal: J Biol Chem ISSN： 0021-9258 Impact factor: 5.157

101 in total

1. Tyrosine phosphorylation of RNA polymerase II carboxyl-terminal domain by the Abl-related gene product.

Authors: R Baskaran; G G Chiang; T Mysliwiec; G D Kruh; J Y Wang
Journal: J Biol Chem Date: 1997-07-25 Impact factor: 5.157

2. Crosstalk between O-GlcNAcylation and proteolytic cleavage regulates the host cell factor-1 maturation pathway.

Authors: Salima Daou; Nazar Mashtalir; Ian Hammond-Martel; Helen Pak; Helen Yu; Guangchao Sui; Jodi L Vogel; Thomas M Kristie; El Bachir Affar
Journal: Proc Natl Acad Sci U S A Date: 2011-02-01 Impact factor: 11.205

3. Beta-N-acetylglucosamine (O-GlcNAc) is part of the histone code.

Authors: Kaoru Sakabe; Zihao Wang; Gerald W Hart
Journal: Proc Natl Acad Sci U S A Date: 2010-11-02 Impact factor: 11.205

4. Phosphorylation of RNAPII: To P-TEFb or not to P-TEFb?

Authors: Bartlomiej Bartkowiak; Arno L Greenleaf
Journal: Transcription Date: 2011-05

5. β-N-Acetylglucosamine (O-GlcNAc) is a novel regulator of mitosis-specific phosphorylations on histone H3.

Authors: Jerry J Fong; Brenda L Nguyen; Robert Bridger; Estela E Medrano; Lance Wells; Shujuan Pan; Richard N Sifers
Journal: J Biol Chem Date: 2012-02-27 Impact factor: 5.157

6. A single nucleotide polymorphism in MGEA5 encoding O-GlcNAc-selective N-acetyl-beta-D glucosaminidase is associated with type 2 diabetes in Mexican Americans.

Authors: Donna M Lehman; Dong-Jing Fu; Angela B Freeman; Kelly J Hunt; Robin J Leach; Teresa Johnson-Pais; Jeanette Hamlington; Thomas D Dyer; Rector Arya; Hanna Abboud; Harald H H Göring; Ravindranath Duggirala; John Blangero; Robert J Konrad; Michael P Stern
Journal: Diabetes Date: 2005-04 Impact factor: 9.461

7. Differential regulation of the ten-eleven translocation (TET) family of dioxygenases by O-linked β-N-acetylglucosamine transferase (OGT).

Authors: Qiao Zhang; Xiaoguang Liu; Wenqi Gao; Pishun Li; Jingli Hou; Jiwen Li; Jiemin Wong
Journal: J Biol Chem Date: 2014-01-06 Impact factor: 5.157

8. Elevated nucleocytoplasmic glycosylation by O-GlcNAc results in insulin resistance associated with defects in Akt activation in 3T3-L1 adipocytes.

Authors: Keith Vosseller; Lance Wells; M Daniel Lane; Gerald W Hart
Journal: Proc Natl Acad Sci U S A Date: 2002-04-16 Impact factor: 11.205

9. The C-terminal domain of RNA polymerase II is modified by site-specific methylation.

Authors: Robert J Sims; Luis Alejandro Rojas; David B Beck; Roberto Bonasio; Roland Schüller; William J Drury; Dirk Eick; Danny Reinberg
Journal: Science Date: 2011-04-01 Impact factor: 47.728

10. Elevated O-GlcNAc-dependent signaling through inducible mOGT expression selectively triggers apoptosis.

Authors: Sang-Hoon Shin; Dona C Love; John A Hanover
Journal: Amino Acids Date: 2010-09-08 Impact factor: 3.520

66 in total

1. Nutrient-deprived cancer cells preferentially use sialic acid to maintain cell surface glycosylation.

Authors: Haitham A Badr; Dina M M AlSadek; Mohit P Mathew; Chen-Zhong Li; Leyla B Djansugurova; Kevin J Yarema; Hafiz Ahmed
Journal: Biomaterials Date: 2015-08-10 Impact factor: 12.479

Review 2. Histone methyltransferases: novel targets for tumor and developmental defects.

Authors: Xin Yi; Xue-Jun Jiang; Xiao-Yan Li; Ding-Sheng Jiang
Journal: Am J Transl Res Date: 2015-11-15 Impact factor: 4.060

3. Liver X receptor regulates hepatic nuclear O-GlcNAc signaling and carbohydrate responsive element-binding protein activity.

Authors: Christian Bindesbøll; Qiong Fan; Rikke C Nørgaard; Laura MacPherson; Hai-Bin Ruan; Jing Wu; Thomas Å Pedersen; Knut R Steffensen; Xiaoyong Yang; Jason Matthews; Susanne Mandrup; Hilde I Nebb; Line M Grønning-Wang
Journal: J Lipid Res Date: 2015-02-27 Impact factor: 5.922

4. Human and rodent temporal lobe epilepsy is characterized by changes in O-GlcNAc homeostasis that can be reversed to dampen epileptiform activity.

Authors: Richard G Sánchez; R Ryley Parrish; Megan Rich; William M Webb; Roxanne M Lockhart; Kazuhito Nakao; Lara Ianov; Susan C Buckingham; Devin R Broadwater; Alistair Jenkins; Nihal C de Lanerolle; Mark Cunningham; Tore Eid; Kristen Riley; Farah D Lubin
Journal: Neurobiol Dis Date: 2019-01-06 Impact factor: 5.996

9. Minireview series on the thirtieth anniversary of research on O-GlcNAcylation of nuclear and cytoplasmic proteins: Nutrient regulation of cellular metabolism and physiology by O-GlcNAcylation.

Authors: Gerald W Hart
Journal: J Biol Chem Date: 2014-10-21 Impact factor: 5.157

10. GM1 Ganglioside is Involved in Epigenetic Activation Loci of Neuronal Cells.

Authors: Yi-Tzang Tsai; Yutaka Itokazu; Robert K Yu
Journal: Neurochem Res Date: 2015-10-24 Impact factor: 3.996