| Literature DB >> 2783195 |
P Schuff-Werner1, G Claus, V W Armstrong, H Köstering, D Seidel.
Abstract
In cultured human monocytes/macrophages, surface expression of procoagulatory activity (PCA) was induced by chemically modified LDL (acetyl-LDL and MDA-LDL) in a dose- and time-dependent manner. Maximum PCA (30-fold increase) was detected after 24 h of culture with modified LDL at doses of 25-750 micrograms protein/ml. Using factor VII deficient human plasma and phospholipase C this PCA was identified as tissue thromboplastin activity (factor III). These results suggest a further atherogenic potential for modified LDL through stimulation of the conversion of fibrinogen to fibrin in the atheromatous lesion.Entities:
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Year: 1989 PMID： 2783195 DOI： 10.1016/0021-9150(89)90214-1
Source DB: PubMed Journal: Atherosclerosis ISSN： 0021-9150 Impact factor: 5.162