Literature DB >> 1752940

Role of oxidized low density lipoprotein in atherogenesis.

J L Witztum1, D Steinberg.   

Abstract

Evidence to support an important role of oxidative modification in mediating the atherogenicity of LDL continues to grow. New hypotheses suggest mechanisms by which Ox-LDL or products of Ox-LDL can affect many components of the atherogenic process, including vasomotor properties and thrombosis, as well as lesion initiation and progression itself. These ideas suggest new approaches, that in combination with lowering of plasma cholesterol, could lead to the prevention of atherosclerosis and its complications.

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Year:  1991        PMID： 1752940      PMCID： PMC295745          DOI： 10.1172/JCI115499

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  60 in total

Review 1.  Arterial metabolism of lipoproteins in relation to atherogenesis.

Authors:  D Steinberg
Journal:  Ann N Y Acad Sci       Date:  1990       Impact factor: 5.691

Review 2.  Lipoproteins and atherogenesis. Current concepts.

Authors:  D Steinberg; J L Witztum
Journal:  JAMA       Date:  1990-12-19       Impact factor: 56.272

3.  Feasibility of using an oleate-rich diet to reduce the susceptibility of low-density lipoprotein to oxidative modification in humans.

Authors:  P Reaven; S Parthasarathy; B J Grasse; E Miller; F Almazan; F H Mattson; J C Khoo; D Steinberg; J L Witztum
Journal:  Am J Clin Nutr       Date:  1991-10       Impact factor: 7.045

4.  Enhanced macrophage degradation of low density lipoprotein previously incubated with cultured endothelial cells: recognition by receptors for acetylated low density lipoproteins.

Authors:  T Henriksen; E M Mahoney; D Steinberg
Journal:  Proc Natl Acad Sci U S A       Date:  1981-10       Impact factor: 11.205

5.  Gene expression in macrophage-rich human atherosclerotic lesions. 15-lipoxygenase and acetyl low density lipoprotein receptor messenger RNA colocalize with oxidation specific lipid-protein adducts.

Authors:  S Ylä-Herttuala; M E Rosenfeld; S Parthasarathy; E Sigal; T Särkioja; J L Witztum; D Steinberg
Journal:  J Clin Invest       Date:  1991-04       Impact factor: 14.808

6.  Minimally modified low density lipoprotein is biologically active in vivo in mice.

Authors:  F Liao; J A Berliner; M Mehrabian; M Navab; L L Demer; A J Lusis; A M Fogelman
Journal:  J Clin Invest       Date:  1991-06       Impact factor: 14.808

7.  Evidence for a dominant role of lipoxygenase(s) in the oxidation of LDL by mouse peritoneal macrophages.

Authors:  S M Rankin; S Parthasarathy; D Steinberg
Journal:  J Lipid Res       Date:  1991-03       Impact factor: 5.922

8.  Macrophage-derived foam cells freshly isolated from rabbit atherosclerotic lesions degrade modified lipoproteins, promote oxidation of low-density lipoproteins, and contain oxidation-specific lipid-protein adducts.

Authors:  M E Rosenfeld; J C Khoo; E Miller; S Parthasarathy; W Palinski; J L Witztum
Journal:  J Clin Invest       Date:  1991-01       Impact factor: 14.808

9.  The antioxidant butylated hydroxytoluene protects against atherosclerosis.

Authors:  I Björkhem; A Henriksson-Freyschuss; O Breuer; U Diczfalusy; L Berglund; P Henriksson
Journal:  Arterioscler Thromb       Date:  1991 Jan-Feb

10.  Preservation of the endogenous antioxidants in low density lipoprotein by ascorbate but not probucol during oxidative modification.

Authors:  I Jialal; S M Grundy
Journal:  J Clin Invest       Date:  1991-02       Impact factor: 14.808
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  390 in total

1.  Is lipid peroxidation relevant to atherogenesis?

Authors:  J W Heinecke
Journal:  J Clin Invest       Date:  1999-07       Impact factor: 14.808

2.  Strategic targeting of atherosclerotic lesions.

Authors:  J Narula; R Virmani; A E Iskandrian
Journal:  J Nucl Cardiol       Date:  1999 Jan-Feb       Impact factor: 5.952

3.  Oxidative modification of lipoproteins in hypertriglyceridemic patients and hypercholesterolemic rabbits in vivo.

Authors:  B W Liu; Y Jiang; M D Fu; Y Liu; P Fan
Journal:  Mol Cell Biochem       Date:  2000-04       Impact factor: 3.396

4.  Hydroxynonenal inactivates cathepsin B by forming Michael adducts with active site residues.

Authors:  John W Crabb; June O'Neil; Masaru Miyagi; Karen West; Henry F Hoff
Journal:  Protein Sci       Date:  2002-04       Impact factor: 6.725

5.  The mechanism of oxidation-induced low-density lipoprotein aggregation: an analogy to colloidal aggregation and beyond?

Authors:  S Xu; B Lin
Journal:  Biophys J       Date:  2001-10       Impact factor: 4.033

6.  Insecticides and atherosclerosis.

Authors:  F C Luft
Journal:  J Mol Med (Berl)       Date:  2001-08       Impact factor: 4.599

7.  Induction of heme oxygenase-1 inhibits the monocyte transmigration induced by mildly oxidized LDL.

Authors:  K Ishikawa; M Navab; N Leitinger; A M Fogelman; A J Lusis
Journal:  J Clin Invest       Date:  1997-09-01       Impact factor: 14.808

Review 8.  The Gordon Wilson Lecture. Plasma cholesterol: atherogenesis and mortality.

Authors:  W R Fisher
Journal:  Trans Am Clin Climatol Assoc       Date:  1993

9.  Molecular imaging of atherosclerotic plaques targeted to oxidized LDL receptor LOX-1 by SPECT/CT and magnetic resonance.

Authors:  Dayuan Li; Amit R Patel; Alexander L Klibanov; Christopher M Kramer; Mirta Ruiz; Bum-Yong Kang; Jawahar L Mehta; George A Beller; David K Glover; Craig H Meyer
Journal:  Circ Cardiovasc Imaging       Date:  2010-05-04       Impact factor: 7.792

10.  Comparison between the effects of intraperitoneal injection of LDL and intravenous injection of LDL on arterial endothelial cells apoptosis.

Authors:  Li Wang; Jin Qin; Zhengxiang Liu
Journal:  J Huazhong Univ Sci Technolog Med Sci       Date:  2003
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