Literature DB >> 27830984

Translating the anticancer properties of eEF2K.

Aude De Gassart1, Fabio Martinon1.   

Abstract

Entities:  

Keywords:  cancer; eEF2K; nelfinavir; protein synthesis; proteostasis; translation elongation

Mesh：

Substances：

Year:  2016        PMID： 27830984      PMCID： PMC5324773          DOI： 10.1080/15384101.2016.1254974

Source DB:  PubMed          Journal:  Cell Cycle        ISSN： 1551-4005            Impact factor:   4.534


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  7 in total

Review 1.  Targeting the translation machinery in cancer.

Authors:  Mamatha Bhat; Nathaniel Robichaud; Laura Hulea; Nahum Sonenberg; Jerry Pelletier; Ivan Topisirovic
Journal:  Nat Rev Drug Discov       Date:  2015-03-06       Impact factor: 84.694

2.  The eEF2 kinase confers resistance to nutrient deprivation by blocking translation elongation.

Authors:  Gabriel Leprivier; Marc Remke; Barak Rotblat; Adrian Dubuc; Abigail-Rachele F Mateo; Marcel Kool; Sameer Agnihotri; Amal El-Naggar; Bin Yu; Syam Prakash Somasekharan; Brandon Faubert; Gaëlle Bridon; Cristina E Tognon; Joan Mathers; Ryan Thomas; Amy Li; Adi Barokas; Brian Kwok; Mary Bowden; Stephanie Smith; Xiaochong Wu; Andrey Korshunov; Thomas Hielscher; Paul A Northcott; Jason D Galpin; Christopher A Ahern; Ye Wang; Martin G McCabe; V Peter Collins; Russell G Jones; Michael Pollak; Olivier Delattre; Martin E Gleave; Eric Jan; Stefan M Pfister; Christopher G Proud; W Brent Derry; Michael D Taylor; Poul H Sorensen
Journal:  Cell       Date:  2013-05-23       Impact factor: 41.582

3.  An inhibitor of HIV-1 protease modulates constitutive eIF2α dephosphorylation to trigger a specific integrated stress response.

Authors:  Aude De Gassart; Bojan Bujisic; Léa Zaffalon; Laurent A Decosterd; Antonia Di Micco; Gianluca Frera; Rémy Tallant; Fabio Martinon
Journal:  Proc Natl Acad Sci U S A       Date:  2015-12-29       Impact factor: 11.205

Review 4.  Eukaryotic elongation factor 2 kinase, an unusual enzyme with multiple roles.

Authors:  Justin W Kenney; Claire E Moore; Xuemin Wang; Christopher G Proud
Journal:  Adv Biol Regul       Date:  2014-04-30

5.  mTORC1-mediated translational elongation limits intestinal tumour initiation and growth.

Authors:  Thomas J Jackson; John Rp Knight; William J Faller; Rachel A Ridgway; Thomas Jamieson; Saadia A Karim; Carolyn Jones; Sorina Radulescu; David J Huels; Kevin B Myant; Kate M Dudek; Helen A Casey; Alessandro Scopelliti; Julia B Cordero; Marcos Vidal; Mario Pende; Alexey G Ryazanov; Nahum Sonenberg; Oded Meyuhas; Michael N Hall; Martin Bushell; Anne E Willis; Owen J Sansom
Journal:  Nature       Date:  2014-11-05       Impact factor: 49.962

Review 6.  Voltage-gated sodium channel as a target for metastatic risk reduction with re-purposed drugs.

Authors:  Tomas Koltai
Journal:  F1000Res       Date:  2015-07-22

7.  Pharmacological eEF2K activation promotes cell death and inhibits cancer progression.

Authors:  Aude De Gassart; Olivier Demaria; Rébecca Panes; Léa Zaffalon; Alexey G Ryazanov; Michel Gilliet; Fabio Martinon
Journal:  EMBO Rep       Date:  2016-08-29       Impact factor: 8.807
  7 in total
  4 in total

1.  Putative genomic characteristics of BRAF V600K versus V600E cutaneous melanoma.

Authors:  Yuanyuan Li; David M Umbach; Leping Li
Journal:  Melanoma Res       Date:  2017-12       Impact factor: 3.599

2.  The role of calcium in the interaction between calmodulin and a minimal functional construct of eukaryotic elongation factor 2 kinase.

Authors:  Kwangwoon Lee; Eric A Kumar; Kevin N Dalby; Ranajeet Ghose
Journal:  Protein Sci       Date:  2019-12       Impact factor: 6.725

Review 3.  Progress in the Development of Eukaryotic Elongation Factor 2 Kinase (eEF2K) Natural Product and Synthetic Small Molecule Inhibitors for Cancer Chemotherapy.

Authors:  Bin Zhang; Jiamei Zou; Qiting Zhang; Ze Wang; Ning Wang; Shan He; Yufen Zhao; C Benjamin Naman
Journal:  Int J Mol Sci       Date:  2021-02-27       Impact factor: 5.923

4.  Activity of translation regulator eukaryotic elongation factor-2 kinase is increased in Parkinson disease brain and its inhibition reduces alpha synuclein toxicity.

Authors:  Asad Jan; Brandon Jansonius; Alberto Delaidelli; Forum Bhanshali; Yi Andy An; Nelson Ferreira; Lisa M Smits; Gian Luca Negri; Jens C Schwamborn; Poul H Jensen; Ian R Mackenzie; Stefan Taubert; Poul H Sorensen
Journal:  Acta Neuropathol Commun       Date:  2018-07-02       Impact factor: 7.801
  4 in total

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