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Literature DB >> 27825848

Pre-mRNA mis-splicing of sarcomeric genes in heart failure.

Abstract

Pre-mRNA splicing is an important biological process that allows production of multiple proteins from a single gene in the genome, and mainly contributes to protein diversity in eukaryotic organisms. Alternative splicing is commonly governed by RNA binding proteins to meet the ever-changing demands of the cell. However, the mis-splicing may lead to human diseases. In the heart of human, mis-regulation of alternative splicing has been associated with heart failure. In this short review, we focus on alternative splicing of sarcomeric genes and review mis-splicing related heart failure with relatively well studied Sarcomeric genes and splicing mechanisms with identified regulatory factors. The perspective of alternative splicing based therapeutic strategies in heart failure has also been discussed.

Entities: Chemical Disease Gene Species

Keywords: Alternative splicing; Heart failure; Sarcomeric genes; Splicing factor

Mesh：

Substances：

Year: 2016 PMID： 27825848 PMCID： PMC5419885 DOI： 10.1016/j.bbadis.2016.11.008

Source DB: PubMed Journal: Biochim Biophys Acta Mol Basis Dis ISSN： 0925-4439 Impact factor: 5.187

106 in total

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15 in total

1. Insulin regulates titin pre-mRNA splicing through the PI3K-Akt-mTOR kinase axis in a RBM20-dependent manner.

Authors: Chaoqun Zhu; Zhiyong Yin; Bihua Tan; Wei Guo
Journal: Biochim Biophys Acta Mol Basis Dis Date: 2017-07-01 Impact factor: 5.187

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Authors: Maimaiti Rexiati; Mingming Sun; Wei Guo
Journal: Genes (Basel) Date: 2018-01-05 Impact factor: 4.096

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Journal: Hum Genet Date: 2017-04-03 Impact factor: 4.132

4. Characterization of TTN Novex Splicing Variants across Species and the Role of RBM20 in Novex-Specific Exon Splicing.

Authors: Zhilong Chen; Jiangping Song; Liang Chen; Chaoqun Zhu; Hanfang Cai; Mingming Sun; Allysa Stern; Paul Mozdziak; Ying Ge; Warrie J Means; Wei Guo
Journal: Genes (Basel) Date: 2018-02-13 Impact factor: 4.096

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Authors: A Beqqali
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6. Angiotensin II Influences Pre-mRNA Splicing Regulation by Enhancing RBM20 Transcription Through Activation of the MAPK/ELK1 Signaling Pathway.

Authors: Hanfang Cai; Chaoqun Zhu; Zhilong Chen; Rexiati Maimaiti; Mingming Sun; Richard J McCormick; Xianyong Lan; Hong Chen; Wei Guo
Journal: Int J Mol Sci Date: 2019-10-12 Impact factor: 5.923

7. QKI is a critical pre-mRNA alternative splicing regulator of cardiac myofibrillogenesis and contractile function.

Authors: Xinyun Chen; Ying Liu; Chen Xu; Lina Ba; Zhuo Liu; Xiuya Li; Jie Huang; Ed Simpson; Hongyu Gao; Dayan Cao; Wei Sheng; Hanping Qi; Hongrui Ji; Maria Sanderson; Chen-Leng Cai; Xiaohui Li; Lei Yang; Jie Na; Kenichi Yamamura; Yunlong Liu; Guoying Huang; Weinian Shou; Ning Sun
Journal: Nat Commun Date: 2021-01-04 Impact factor: 14.919