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Literature DB >> 25446994

Sarcomeric protein isoform transitions in cardiac muscle: a journey to heart failure.

Abstract

Sarcomeric protein isoforms are mainly governed by alternative promoter-driven expression, distinct gene expression, gene mutation and alternative mRNA splicing. The transitions of sarcomeric proteins have been implicated to play a role in the onset and development of human heart failure. In this mini-review, we summarized isoform transitions of several most widely examined sarcomeric proteins including myosin, actin, troponin, tropomyosin, titin and myosin binding protein-C, and the consequence of these abnormal isoform transitions. Even though the isoform transitions of sarcomeric proteins have been described in individual sarcomeric protein reviews, no concise summary of these results has been presented previously. This review is intended to fill this gap and discuss possible future perspectives.

Entities: Chemical Disease Gene Species

Keywords: Alternative splicing; Heart failure; Protein isoform transition; Sarcomere proteins

Mesh：

Substances：

Year: 2014 PMID： 25446994 PMCID： PMC4268308 DOI： 10.1016/j.bbadis.2014.11.003

Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002

88 in total

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45 in total

1. Cardiomyocyte cell cycling, maturation, and growth by multinucleation in postnatal swine.

Authors: Nivedhitha Velayutham; Christina M Alfieri; Emma J Agnew; Kyle W Riggs; R Scott Baker; Sithara Raju Ponny; Farhan Zafar; Katherine E Yutzey
Journal: J Mol Cell Cardiol Date: 2020-07-22 Impact factor: 5.000

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Authors: Eunjin Cho; HyunJun Kang; Dae-Ki Kang; Youngsook Lee
Journal: J Biol Chem Date: 2019-01-30 Impact factor: 5.157