| Literature DB >> 27818083 |
Hailiang Xie1, Ruijin Guo2, Huanzi Zhong1, Qiang Feng3, Zhou Lan4, Bingcai Qin4, Kirsten J Ward5, Matthew A Jackson5, Yan Xia6, Xu Chen7, Bing Chen1, Huihua Xia8, Changlu Xu7, Fei Li9, Xun Xu1, Jumana Yousuf Al-Aama4, Huanming Yang10, Jian Wang10, Karsten Kristiansen11, Jun Wang12, Claire J Steves5, Jordana T Bell5, Junhua Li13, Timothy D Spector14, Huijue Jia15.
Abstract
The gut microbiota has been typically viewed as an environmental factor for human health. Twins are well suited for investigating the concordance of their gut microbiomes and decomposing genetic and environmental influences. However, existing twin studies utilizing metagenomic shotgun sequencing have included only a few samples. Here, we sequenced fecal samples from 250 adult twins in the TwinsUK registry and constructed a comprehensive gut microbial reference gene catalog. We demonstrate heritability of many microbial taxa and functional modules in the gut microbiome, including those associated with diseases. Moreover, we identified 8 million SNPs in the gut microbiome and observe a high similarity in microbiome SNPs between twins that slowly decreases after decades of living apart. The results shed new light on the genetic and environmental influences on the composition and function of the gut microbiome that could relate to risk of complex diseases.Entities:
Keywords: SNPs; heritability; metabolic diseases; microbiome
Year: 2016 PMID： 27818083 PMCID： PMC6309625 DOI： 10.1016/j.cels.2016.10.004
Source DB: PubMed Journal: Cell Syst ISSN： 2405-4712 Impact factor: 10.304