| Literature DB >> 27814994 |
Ziv Gan-Or1, Jacques Y Montplaisir2, Jay P Ross3, Judes Poirier4, Simon C Warby2, Isabelle Arnulf5, Stephanie Strong6, Yves Dauvilliers7, Claire S Leblond8, Michele T M Hu9, Birgit Högl10, Ambra Stefani10, Christelle Charley Monaca11, Valérie Cochen De Cock12, Michel Boivin13, Luigi Ferini-Strambi14, Giuseppe Plazzi15, Elena Antelmi16, Peter Young17, Anna Heidbreder17, Thomas R Barber9, Samuel G Evetts9, Michal Rolinski9, Patrick A Dion18, Alex Desautels19, Jean-François Gagnon20, Nicolas Dupré21, Ronald B Postuma22, Guy A Rouleau23.
Abstract
The present study aimed to examine whether the APOE ε4 allele, associated with dementia with Lewy bodies (DLB), and possibly with dementia in Parkinson's disease (PD), is also associated with idiopathic rapid eye movement sleep behavior disorder (RBD). Two single nucleotide polymorphisms, rs429358 and rs7412, were genotyped in RBD patients (n = 480) and in controls (n = 823). APOE ε4 allele frequency was 0.14 among RBD patients and 0.13 among controls (OR = 1.11, 95% CI: 0.88-1.40, p = 0.41). APOE ε4 allele frequencies were similar in those who converted to DLB (0.14) and those who converted to Parkinson's disease (0.12) or multiple system atrophy (0.14, p = 1.0). The APOE ε4 allele is neither a risk factor for RBD nor it is associated with conversion from RBD to DLB or other synucleinopathies.Entities:
Keywords: APOE; Dementia with Lewy bodies; Genetics; Parkinson's disease; REM sleep behavior disorder
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Year: 2016 PMID： 27814994 DOI： 10.1016/j.neurobiolaging.2016.10.002
Source DB: PubMed Journal: Neurobiol Aging ISSN： 0197-4580 Impact factor: 4.673