Tenghui Zhang1, Chao Ding2, Tingbin Xie3, Jianbo Yang4, Xujie Dai5, Tengfei Lv6, Yi Li7, Lili Gu8, Yao Wei9, Jianfeng Gong10, Weiming Zhu11, Ning Li12, Jieshou Li13. 1. Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China. Electronic address: tenghuiff@163.com. 2. Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China. Electronic address: dingchao19910521@126.com. 3. Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China. Electronic address: 18351875182@163.com. 4. Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China. Electronic address: yang_jianbo@126.com. 5. Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China. Electronic address: d670677094@163.com. 6. Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China. Electronic address: itengfeilv@163.com. 7. Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China. Electronic address: liyi1860@126.com. 8. Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China. Electronic address: drgulili@163.com. 9. Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China. Electronic address: dr_betty@126.com. 10. Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China. Electronic address: gongjianfeng@aliyun.com. 11. Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China. Electronic address: dr_zhuweiming@126.com. 12. Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China. Electronic address: liningrigs@vip.sina.com. 13. Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China. Electronic address: lijieshounj@163.com.
Abstract
BACKGROUND & AIMS: The body composition of patients with ulcerative colitis (UC) remains unclear. This study evaluated body composition in adult patients with UC and the associations of body composition with disease activity and surgical intervention. METHODS: This study included 99 patients with UC, 105 with Crohn's disease (CD) and 60 controls. Skeletal muscle area (SMA), visceral fat area (VFA) and subcutaneous fat area (SFA) of the third lumbar vertebrae were evaluated by abdominal computed tomography. The effects of medical therapy and surgery on body composition in UC patients were determined. RESULTS: Sarcopenia was more frequent in UC patients (27.3%) than in controls (8.3%), but less frequent than in CD patients (59.0%). The prevalence of sarcopenia was significantly higher (33.8% vs. 4.5%, p < 0.001), and SMA (144.26 vs. 182.32 cm2, p < 0.001), skeletal muscle index (SMI) (52.22 vs. 65.52 cm2/m2, p < 0.001) significantly lower, in UC patients with high (≥6) than low (<6) Mayo score, but SFA and VFA were similar. The prevalence of sarcopenia and alterations in body composition were reversed, along with UC disease activity, following medical treatment or surgery. SMA and SMI correlated significantly with disease activity in UC patients. Multivariate analysis showed that sarcopenia (odds ratio, 8.49; 95% confidence interval, 1.80-40.10; p = 0.007) was a negative predictor of high Mayo score in UC patients. Sarcopenic patients with UC had high probability of need for colectomy in Kaplan-Meier survival curves. CONCLUSIONS: Sarcopenia is associated with high disease activity and poor clinical outcome in UC patients. Medical treatment and colectomy have positive effects on sarcopenia and skeletal muscle depletion.
BACKGROUND & AIMS: The body composition of patients with ulcerative colitis (UC) remains unclear. This study evaluated body composition in adult patients with UC and the associations of body composition with disease activity and surgical intervention. METHODS: This study included 99 patients with UC, 105 with Crohn's disease (CD) and 60 controls. Skeletal muscle area (SMA), visceral fat area (VFA) and subcutaneous fat area (SFA) of the third lumbar vertebrae were evaluated by abdominal computed tomography. The effects of medical therapy and surgery on body composition in UC patients were determined. RESULTS:Sarcopenia was more frequent in UC patients (27.3%) than in controls (8.3%), but less frequent than in CDpatients (59.0%). The prevalence of sarcopenia was significantly higher (33.8% vs. 4.5%, p < 0.001), and SMA (144.26 vs. 182.32 cm2, p < 0.001), skeletal muscle index (SMI) (52.22 vs. 65.52 cm2/m2, p < 0.001) significantly lower, in UC patients with high (≥6) than low (<6) Mayo score, but SFA and VFA were similar. The prevalence of sarcopenia and alterations in body composition were reversed, along with UC disease activity, following medical treatment or surgery. SMA and SMI correlated significantly with disease activity in UC patients. Multivariate analysis showed that sarcopenia (odds ratio, 8.49; 95% confidence interval, 1.80-40.10; p = 0.007) was a negative predictor of high Mayo score in UC patients. Sarcopenic patients with UC had high probability of need for colectomy in Kaplan-Meier survival curves. CONCLUSIONS:Sarcopenia is associated with high disease activity and poor clinical outcome in UC patients. Medical treatment and colectomy have positive effects on sarcopenia and skeletal muscle depletion.
Authors: Kelly C Cushing; Hamed Kordbacheh; Michael S Gee; Avinash Kambadakone; Ashwin N Ananthakrishnan Journal: J Crohns Colitis Date: 2018-08-29 Impact factor: 9.071
Authors: Nik Sheng Ding; Daniel Tassone; Ibrahim Al Bakir; Kyle Wu; Alexander J Thompson; William R Connell; George Malietzis; Phillip Lung; Siddharth Singh; Chang-Ho Ryan Choi; Simon Gabe; John T Jenkins; Ailsa Hart Journal: J Crohns Colitis Date: 2022-09-08 Impact factor: 10.020
Authors: Stephen O'Brien; Richard G Kavanagh; Brian W Carey; Michael M Maher; Owen J O'Connor; Emmet J Andrews Journal: Eur Radiol Exp Date: 2018-11-21
Authors: Francesco Palmese; Rossella Del Toro; Giulia Di Marzio; Pierluigi Cataleta; Maria Giulia Sama; Marco Domenicali Journal: Nutrients Date: 2021-04-20 Impact factor: 5.717
Authors: Hyo Jin An; Kalthoum Tizaoui; Salvatore Terrazzino; Sarah Cargnin; Keum Hwa Lee; Seoung Wan Nam; Jae Seok Kim; Jae Won Yang; Jun Young Lee; Lee Smith; Ai Koyanagi; Louis Jacob; Han Li; Jae Il Shin; Andreas Kronbichler Journal: Int J Mol Sci Date: 2020-08-07 Impact factor: 5.923